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FRS2 [plasma membrane]
Stable Identifier
R-BTA-170963
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
FRS2, E1B7I9
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
RET signaling (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
FRS-mediated FGFR1 signaling (Bos taurus)
Activated FGFR1 binds FRS2 (Bos taurus)
Activated FGFR1:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Activated FGFR1 phosphorylates FRS2 (Bos taurus)
Activated FGFR1:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Bos taurus)
Activated FGFR1:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
FRS-mediated FGFR2 signaling (Bos taurus)
Activated FGFR2 binds FRS2 (Bos taurus)
Activated FGFR2:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Activated FGFR2 phosphorylates FRS2 (Bos taurus)
Activated FGFR2:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)
Activated FGFR2:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
FRS-mediated FGFR3 signaling (Bos taurus)
Activated FGFR3 binds FRS2 (Bos taurus)
Activated FGFR3:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Activated FGFR3 phosphorylates FRS2 (Bos taurus)
Activated FGFR3:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Bos taurus)
Activated FGFR3:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4 binds FRS2 (Bos taurus)
Activated FGFR4:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 phosphorylates FRS2 (Bos taurus)
Activated FGFR4:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Bos taurus)
Activated FGFR4:FRS2 [plasma membrane] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RND1 GTPase cycle (Bos taurus)
RND1 binds effectors (Bos taurus)
RND1 effectors [cytosol] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
RND1:GTP:RND1 effectors [plasma membrane] (Bos taurus)
RND1 effectors [cytosol] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
RND2 GTPase cycle (Bos taurus)
RND2 binds effectors (Bos taurus)
RND2 effectors [cytosol] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
RND2:GTP:RND2 effectors [plasma membrane] (Bos taurus)
RND2 effectors [cytosol] (Bos taurus)
FRS2 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:E1B7I9
Gene Names
FRS2
Reference Genes
BioGPS Gene:538624 FRS2
ENSEMBL:ENSBTAG00000019155.4
ENSEMBL:ENSBTAG00000019155.5 FRS2
KEGG Gene (Bos taurus):538624 FRS2
Monarch:538624 FRS2
NCBI Gene:538624 FRS2
Reference Transcript
RefSeq:XM_010805102.2 FRS2
RefSeq:XM_010827723.2 FRS2
RefSeq:XM_581582.8 FRS2
RefSeq:XM_010805103.2 FRS2
RefSeq:XM_010827722.2 FRS2
RefSeq:XM_002687385.5 FRS2
Other Identifiers
538624
GO:0001702
GO:0001759
GO:0002088
GO:0003281
GO:0005068
GO:0005104
GO:0005168
GO:0005737
GO:0005886
GO:0005911
GO:0005912
GO:0007169
GO:0007405
GO:0008543
GO:0008595
GO:0012501
GO:0016020
GO:0022414
GO:0023052
GO:0030154
GO:0030900
GO:0042981
GO:0043410
GO:0046619
GO:0048856
GO:0050678
GO:0060090
GO:0060527
GO:0070307
GO:0070372
GO:2000726
Participates
as a member of
RND2 effectors [cytosol] (Bos taurus)
RND1 effectors [cytosol] (Bos taurus)
as an input of
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Bos taurus)
Activated FGFR4 binds FRS2 (Bos taurus)
Activated FGFR1 binds FRS2 (Bos taurus)
Activated FGFR3 binds FRS2 (Bos taurus)
Activated FGFR2 binds FRS2 (Bos taurus)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4:FRS2 [plasma membrane] (Bos taurus)
Activated FGFR1:FRS2 [plasma membrane] (Bos taurus)
Activated FGFR3:FRS2 [plasma membrane] (Bos taurus)
Activated FGFR2:FRS2 [plasma membrane] (Bos taurus)
Other forms of this molecule
phospho-FRS2 [cytosol]
FRS2 [cytosol]
phospho-FRS2 [cytosol]
phospho-FRS2 [plasma membrane]
phospho-FRS2 [plasma membrane]
Inferred From
FRS2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_010803404.1
,
XP_581582.1
,
XP_010826024.1
,
XP_010803405.1
,
XP_010826025.1
,
XP_002687431.1
OpenTargets
ENSG00000166225
Ensembl
ENSBTAG00000019155
,
ENSBTAT00000025495
,
ENSBTAP00000025495
VGNC
29120
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