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Fe2+ [cytosol]
Stable Identifier
R-ALL-71067
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
iron (ferrous), iron atom, Fe(II), Fe++, Iron, Fe3+, Fe(III)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
Fe2+ [cytosol]
Cellular response to hypoxia (Bos taurus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
FIH1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
VBC complex (with or without LIMD1) [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
Ion influx/efflux at host-pathogen interface (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP2, IP, and Ins in the cytosol (Bos taurus)
MIOX oxidises Ins to GlcA (Bos taurus)
MIOX:2xFe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Carnitine synthesis (Bos taurus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
BBOX1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Bos taurus)
Catecholamine biosynthesis (Bos taurus)
Tyrosine is hydroxylated to dopa (Bos taurus)
TH:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Bos taurus)
Tryptophan is hydroxylated (Bos taurus)
TPH:Fe++ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Phenylalanine metabolism (Bos taurus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
PAH:Fe2+ tetramer [cytosol] (Bos taurus)
Fe2+ [cytosol]
Tyrosine catabolism (Bos taurus)
homogentisate + O2 => maleylacetoacetate (Bos taurus)
HGD hexamer [cytosol] (Bos taurus)
Fe2+ [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Bos taurus)
HPD:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Bos taurus)
Degradation of cysteine and homocysteine (Bos taurus)
ADO oxidises 2AET to HTAU (Bos taurus)
ADO:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Bos taurus)
CDO1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Methionine salvage pathway (Bos taurus)
Acireductone is oxidized to MOB (Bos taurus)
ARD:Fe++ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Tryptophan catabolism (Bos taurus)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)
HAAO [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of carbohydrates (Bos taurus)
Pentose phosphate pathway (Bos taurus)
RPE dimers isomerise RU5P to XY5P (Bos taurus)
RPE:Fe2+ dimers [cytosol] (Bos taurus)
RPE:Fe2+ dimer [cytosol] (Bos taurus)
RPE:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Bos taurus)
RPEL1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)
RPE:Fe2+ dimers [cytosol] (Bos taurus)
RPE:Fe2+ dimer [cytosol] (Bos taurus)
RPE:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Bos taurus)
RPEL1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of DHA-derived SPMs (Bos taurus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Bos taurus)
Biosynthesis of DPAn-3 SPMs (Bos taurus)
Biosynthesis of DPAn-3-derived maresins (Bos taurus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Bos taurus)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Bos taurus)
ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of 12-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Bos taurus)
ALOX12B:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Bos taurus)
ALOX12/15 [cytosol] (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Bos taurus)
ALOX15/15B [cytosol] (Bos taurus)
ALOX15:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Bos taurus)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)
ALOX5:Ca2+:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Bos taurus)
ALOX15:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme degradation (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of fat-soluble vitamins (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)
BCMO1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Bos taurus)
Hypusine synthesis from eIF5A-lysine (Bos taurus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
DOHH:Fe++ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)
BCMO1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Bos taurus)
PP1A(Fe and Mn cofactors) [cytosol] (Bos taurus)
Fe2+ [cytosol]
Transport of small molecules (Bos taurus)
Iron uptake and transport (Bos taurus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Bos taurus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
Fe2+ [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
VBC complex (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Immune System (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Antimicrobial peptides (Caenorhabditis elegans)
Ion influx/efflux at host-pathogen interface (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
MIOX:2xFe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Carnitine synthesis (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Catecholamine biosynthesis (Caenorhabditis elegans)
Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)
TH:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Caenorhabditis elegans)
Tryptophan is hydroxylated (Caenorhabditis elegans)
TPH:Fe++ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
PAH:Fe2+ tetramer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Tyrosine catabolism (Caenorhabditis elegans)
homogentisate + O2 => maleylacetoacetate (Caenorhabditis elegans)
HGD hexamer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Caenorhabditis elegans)
HPD:AscH-:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
ADO oxidises 2AET to HTAU (Caenorhabditis elegans)
ADO:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)
CDO1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Methionine salvage pathway (Caenorhabditis elegans)
Acireductone is oxidized to MOB (Caenorhabditis elegans)
ARD:Fe++ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)
HAAO [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Pentose phosphate pathway (Caenorhabditis elegans)
RPE dimers isomerise RU5P to XY5P (Caenorhabditis elegans)
RPE:Fe2+ dimers [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
RPEL1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)
RPE:Fe2+ dimers [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
RPEL1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of fat-soluble vitamins (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)
BCMO1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Caenorhabditis elegans)
Hypusine synthesis from eIF5A-lysine (Caenorhabditis elegans)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
DOHH:Fe++ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)
BCMO1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Transport of small molecules (Caenorhabditis elegans)
Iron uptake and transport (Caenorhabditis elegans)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Caenorhabditis elegans)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)
Fe2+ [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
Fe2+ [cytosol]
Cellular response to hypoxia (Canis familiaris)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)
FIH1:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
FIH1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
VBC complex (with or without LIMD1) [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
MIOX oxidises Ins to GlcA (Canis familiaris)
MIOX:2xFe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Carnitine synthesis (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
BBOX1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Canis familiaris)
Catecholamine biosynthesis (Canis familiaris)
Tyrosine is hydroxylated to dopa (Canis familiaris)
TH:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Canis familiaris)
Tryptophan is hydroxylated (Canis familiaris)
TPH:Fe++ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
PAH:Fe2+ tetramer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Tyrosine catabolism (Canis familiaris)
homogentisate + O2 => maleylacetoacetate (Canis familiaris)
HGD hexamer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Canis familiaris)
HPD:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
Degradation of cysteine and homocysteine (Canis familiaris)
ADO oxidises 2AET to HTAU (Canis familiaris)
ADO:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Canis familiaris)
CDO1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Methionine salvage pathway (Canis familiaris)
Acireductone is oxidized to MOB (Canis familiaris)
ARD:Fe++ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Tryptophan catabolism (Canis familiaris)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Canis familiaris)
HAAO [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Pentose phosphate pathway (Canis familiaris)
RPE dimers isomerise RU5P to XY5P (Canis familiaris)
RPE:Fe2+ dimers [cytosol] (Canis familiaris)
RPE:Fe2+ dimer [cytosol] (Canis familiaris)
RPE:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Canis familiaris)
RPEL1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)
RPE:Fe2+ dimers [cytosol] (Canis familiaris)
RPE:Fe2+ dimer [cytosol] (Canis familiaris)
RPE:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Canis familiaris)
RPEL1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Synthesis of 12-eicosatetraenoic acid derivatives (Canis familiaris)
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)
ALOX12B:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)
ALOX15:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Canis familiaris)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Canis familiaris)
ALOX15/15B [cytosol] (Canis familiaris)
ALOX15:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
LTA4 is converted to EXA4 by ALOX15 (Canis familiaris)
ALOX15:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme degradation (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of fat-soluble vitamins (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)
BCMO1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Canis familiaris)
Hypusine synthesis from eIF5A-lysine (Canis familiaris)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
DOHH:Fe++ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)
BCMO1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
DARPP-32 events (Canis familiaris)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Canis familiaris)
PP1A(Fe and Mn cofactors) [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Transport of small molecules (Canis familiaris)
Iron uptake and transport (Canis familiaris)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
Fe2+ [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
Fe2+ [cytosol]
Cellular response to hypoxia (Danio rerio)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)
FIH1:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
FIH1:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Danio rerio)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Danio rerio)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Danio rerio)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Danio rerio)
PHD2,3 [cytosol] (Danio rerio)
EGLN1:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Danio rerio)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Danio rerio)
PHD2,3 [cytosol] (Danio rerio)
EGLN1:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Danio rerio)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Danio rerio)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Danio rerio)
PHD2,3 [cytosol] (Danio rerio)
EGLN1:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism (Danio rerio)
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP2, IP, and Ins in the cytosol (Danio rerio)
MIOX oxidises Ins to GlcA (Danio rerio)
MIOX:2xFe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Carnitine synthesis (Danio rerio)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
BBOX1:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Danio rerio)
Catecholamine biosynthesis (Danio rerio)
Tyrosine is hydroxylated to dopa (Danio rerio)
TH:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Danio rerio)
Tryptophan is hydroxylated (Danio rerio)
TPH:Fe++ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
PAH:Fe2+ tetramer [cytosol] (Danio rerio)
Fe2+ [cytosol]
Tyrosine catabolism (Danio rerio)
homogentisate + O2 => maleylacetoacetate (Danio rerio)
HGD hexamer [cytosol] (Danio rerio)
Fe2+ [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Danio rerio)
HPD:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Danio rerio)
Degradation of cysteine and homocysteine (Danio rerio)
ADO oxidises 2AET to HTAU (Danio rerio)
ADO:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)
CDO1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Methionine salvage pathway (Danio rerio)
Acireductone is oxidized to MOB (Danio rerio)
ARD:Fe++ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Tryptophan catabolism (Danio rerio)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)
HAAO [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of carbohydrates (Danio rerio)
Pentose phosphate pathway (Danio rerio)
RPE dimers isomerise RU5P to XY5P (Danio rerio)
RPE:Fe2+ dimers [cytosol] (Danio rerio)
RPE:Fe2+ dimer [cytosol] (Danio rerio)
RPE:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Danio rerio)
RPEL1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)
RPE:Fe2+ dimers [cytosol] (Danio rerio)
RPE:Fe2+ dimer [cytosol] (Danio rerio)
RPE:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Danio rerio)
RPEL1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of DHA-derived SPMs (Danio rerio)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Danio rerio)
Biosynthesis of DPAn-3 SPMs (Danio rerio)
Biosynthesis of DPAn-3-derived maresins (Danio rerio)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Danio rerio)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Danio rerio)
ALOX12 oxidises LTA4 to LXA4/B4 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Synthesis of 12-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Danio rerio)
ALOX12B:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Danio rerio)
ALOX12/15 [cytosol] (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Danio rerio)
ALOX15/15B [cytosol] (Danio rerio)
ALOX15:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Danio rerio)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
ALOX5 is phosphorylated by MAPKAP2 (Danio rerio)
ALOX5:Ca2+:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Danio rerio)
ALOX15:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Synthesis of bile acids and bile salts (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Danio rerio)
Fe2+ [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme degradation (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of fat-soluble vitamins (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)
BCMO1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Danio rerio)
Hypusine synthesis from eIF5A-lysine (Danio rerio)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
DOHH:Fe++ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Sensory Perception (Danio rerio)
Visual phototransduction (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)
BCMO1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Opioid Signalling (Danio rerio)
DARPP-32 events (Danio rerio)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Danio rerio)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Danio rerio)
PP1A(Fe and Mn cofactors) [cytosol] (Danio rerio)
Fe2+ [cytosol]
Transport of small molecules (Danio rerio)
Iron uptake and transport (Danio rerio)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Danio rerio)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Metal ion SLC transporters (Danio rerio)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
Fe2+ [cytosol]
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
Antimicrobial peptides (Dictyostelium discoideum)
Ion influx/efflux at host-pathogen interface (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Dictyostelium discoideum)
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP2, IP, and Ins in the cytosol (Dictyostelium discoideum)
MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
MIOX:2xFe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Catecholamine biosynthesis (Dictyostelium discoideum)
Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)
TH:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Dictyostelium discoideum)
Tryptophan is hydroxylated (Dictyostelium discoideum)
TPH:Fe++ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
PAH:Fe2+ tetramer [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Tyrosine catabolism (Dictyostelium discoideum)
homogentisate + O2 => maleylacetoacetate (Dictyostelium discoideum)
HGD hexamer [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Dictyostelium discoideum)
HPD:AscH-:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
ADO oxidises 2AET to HTAU (Dictyostelium discoideum)
ADO:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)
CDO1:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Methionine salvage pathway (Dictyostelium discoideum)
Acireductone is oxidized to MOB (Dictyostelium discoideum)
ARD:Fe++ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Dictyostelium discoideum)
HAAO [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Pentose phosphate pathway (Dictyostelium discoideum)
RPE dimers isomerise RU5P to XY5P (Dictyostelium discoideum)
RPE:Fe2+ dimers [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
RPEL1:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)
RPE:Fe2+ dimers [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
RPEL1:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Biosynthesis of specialized proresolving mediators (SPMs) (Dictyostelium discoideum)
Biosynthesis of DHA-derived SPMs (Dictyostelium discoideum)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of DPAn-3 SPMs (Dictyostelium discoideum)
Biosynthesis of DPAn-3-derived maresins (Dictyostelium discoideum)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Dictyostelium discoideum)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Dictyostelium discoideum)
ALOX12 oxidises LTA4 to LXA4/B4 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonic acid metabolism (Dictyostelium discoideum)
Synthesis of 12-eicosatetraenoic acid derivatives (Dictyostelium discoideum)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)
ALOX12B:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Dictyostelium discoideum)
ALOX12/15 [cytosol] (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Dictyostelium discoideum)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)
ALOX15/15B [cytosol] (Dictyostelium discoideum)
ALOX15:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Dictyostelium discoideum)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Dictyostelium discoideum)
LTA4 is converted to EXA4 by ALOX15 (Dictyostelium discoideum)
ALOX15:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of steroids (Dictyostelium discoideum)
Bile acid and bile salt metabolism (Dictyostelium discoideum)
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Dictyostelium discoideum)
Hypusine synthesis from eIF5A-lysine (Dictyostelium discoideum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
DOHH:Fe++ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Transport of small molecules (Dictyostelium discoideum)
Iron uptake and transport (Dictyostelium discoideum)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Dictyostelium discoideum)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
Metal ion SLC transporters (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
Fe2+ [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
VBC complex (with or without LIMD1) [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Antimicrobial peptides (Drosophila melanogaster)
Ion influx/efflux at host-pathogen interface (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Drosophila melanogaster)
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP2, IP, and Ins in the cytosol (Drosophila melanogaster)
MIOX oxidises Ins to GlcA (Drosophila melanogaster)
MIOX:2xFe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Carnitine synthesis (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Drosophila melanogaster)
Catecholamine biosynthesis (Drosophila melanogaster)
Tyrosine is hydroxylated to dopa (Drosophila melanogaster)
TH:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Drosophila melanogaster)
Tryptophan is hydroxylated (Drosophila melanogaster)
TPH:Fe++ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
PAH:Fe2+ tetramer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Tyrosine catabolism (Drosophila melanogaster)
homogentisate + O2 => maleylacetoacetate (Drosophila melanogaster)
HGD hexamer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Drosophila melanogaster)
HPD:AscH-:Fe2+ dimer [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Drosophila melanogaster)
Degradation of cysteine and homocysteine (Drosophila melanogaster)
ADO oxidises 2AET to HTAU (Drosophila melanogaster)
ADO:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)
CDO1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Methionine salvage pathway (Drosophila melanogaster)
Acireductone is oxidized to MOB (Drosophila melanogaster)
ARD:Fe++ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Pentose phosphate pathway (Drosophila melanogaster)
RPE dimers isomerise RU5P to XY5P (Drosophila melanogaster)
RPE:Fe2+ dimers [cytosol] (Drosophila melanogaster)
RPE:Fe2+ dimer [cytosol] (Drosophila melanogaster)
RPE:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Drosophila melanogaster)
RPEL1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)
RPE:Fe2+ dimers [cytosol] (Drosophila melanogaster)
RPE:Fe2+ dimer [cytosol] (Drosophila melanogaster)
RPE:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Drosophila melanogaster)
RPEL1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of fat-soluble vitamins (Drosophila melanogaster)
Retinoid metabolism and transport (Drosophila melanogaster)
BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)
BCMO1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Drosophila melanogaster)
Hypusine synthesis from eIF5A-lysine (Drosophila melanogaster)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)
DOHH:Fe++ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
Retinoid metabolism and transport (Drosophila melanogaster)
BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)
BCMO1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Transport of small molecules (Drosophila melanogaster)
Iron uptake and transport (Drosophila melanogaster)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Drosophila melanogaster)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Metal ion SLC transporters (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
Fe2+ [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Cytoprotection by HMOX1 (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
Fe2+ [cytosol]
Cellular response to hypoxia (Gallus gallus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
FIH1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Gallus gallus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Ion influx/efflux at host-pathogen interface (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Gallus gallus)
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP2, IP, and Ins in the cytosol (Gallus gallus)
MIOX oxidises Ins to GlcA (Gallus gallus)
MIOX:2xFe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Carnitine synthesis (Gallus gallus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Gallus gallus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
BBOX1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Gallus gallus)
Catecholamine biosynthesis (Gallus gallus)
Tyrosine is hydroxylated to dopa (Gallus gallus)
TH:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Gallus gallus)
Tryptophan is hydroxylated (Gallus gallus)
TPH:Fe++ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Gallus gallus)
Phenylalanine metabolism (Gallus gallus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)
PAH:Fe2+ tetramer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Tyrosine catabolism (Gallus gallus)
homogentisate + O2 => maleylacetoacetate (Gallus gallus)
HGD hexamer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Gallus gallus)
HPD:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
Degradation of cysteine and homocysteine (Gallus gallus)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Gallus gallus)
CDO1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Methionine salvage pathway (Gallus gallus)
Acireductone is oxidized to MOB (Gallus gallus)
ARD:Fe++ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Tryptophan catabolism (Gallus gallus)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Gallus gallus)
HAAO [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of carbohydrates (Gallus gallus)
Pentose phosphate pathway (Gallus gallus)
RPE dimers isomerise RU5P to XY5P (Gallus gallus)
RPE:Fe2+ dimers [cytosol] (Gallus gallus)
RPE:Fe2+ dimer [cytosol] (Gallus gallus)
RPE:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Gallus gallus)
RPEL1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Gallus gallus)
RPE:Fe2+ dimers [cytosol] (Gallus gallus)
RPE:Fe2+ dimer [cytosol] (Gallus gallus)
RPE:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Gallus gallus)
RPEL1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of lipids (Gallus gallus)
Fatty acid metabolism (Gallus gallus)
Arachidonic acid metabolism (Gallus gallus)
Synthesis of 12-eicosatetraenoic acid derivatives (Gallus gallus)
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Gallus gallus)
ALOX12B:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Gallus gallus)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Gallus gallus)
ALOX15B:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Gallus gallus)
ALOX5 is phosphorylated by MAPKAP2 (Gallus gallus)
ALOX5:Ca2+:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of steroids (Gallus gallus)
Bile acid and bile salt metabolism (Gallus gallus)
Synthesis of bile acids and bile salts (Gallus gallus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of nucleotides (Gallus gallus)
Nucleotide biosynthesis (Gallus gallus)
Purine ribonucleoside monophosphate biosynthesis (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of porphyrins (Gallus gallus)
Heme degradation (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of fat-soluble vitamins (Gallus gallus)
Retinoid metabolism and transport (Gallus gallus)
BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)
BCMO1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Gallus gallus)
Hypusine synthesis from eIF5A-lysine (Gallus gallus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)
DOHH:Fe++ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Sensory Perception (Gallus gallus)
Visual phototransduction (Gallus gallus)
Retinoid metabolism and transport (Gallus gallus)
BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)
BCMO1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Transport of small molecules (Gallus gallus)
Iron uptake and transport (Gallus gallus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Gallus gallus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Metal ion SLC transporters (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
Fe2+ [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
Fe2+ [cytosol]
Cellular response to hypoxia (Homo sapiens)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)
FIH1:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
FIH1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Phenylketonuria (Homo sapiens)
Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)
PAH S40L:Fe2+ tetramer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) (Homo sapiens)
Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
Infectious disease (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
Mtb iron assimilation by chelation (Homo sapiens)
BfrA stores iron (Homo sapiens)
Fe2+ [cytosol]
BfrB stores iron (Homo sapiens)
Fe2+ [cytosol]
Iron is reduced and separates from mycobactin (Homo sapiens)
Fe2+ [cytosol]
Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
SodB reduces superoxide to H2O2 (Homo sapiens)
SodB tetramer [cytosol] (Mycobacterium tuberculosis)
Fe2+ [cytosol]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Ion influx/efflux at host-pathogen interface (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Homo sapiens)
Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)
Fe2+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Superoxide anion reacts with Fe-S cluster (Homo sapiens)
Fe2+ [cytosol]
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
MIOX oxidises Ins to GlcA (Homo sapiens)
MIOX:2xFe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Carnitine synthesis (Homo sapiens)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
BBOX1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Homo sapiens)
Catecholamine biosynthesis (Homo sapiens)
Tyrosine is hydroxylated to dopa (Homo sapiens)
TH:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Homo sapiens)
Tryptophan is hydroxylated (Homo sapiens)
TPH:Fe++ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Phenylalanine metabolism (Homo sapiens)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
PAH:Fe2+ tetramer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Tyrosine catabolism (Homo sapiens)
homogentisate + O2 => maleylacetoacetate (Homo sapiens)
HGD hexamer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Homo sapiens)
HPD:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
ADO oxidises 2AET to HTAU (Homo sapiens)
ADO:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Homo sapiens)
CDO1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Methionine salvage pathway (Homo sapiens)
Acireductone is oxidized to MOB (Homo sapiens)
ARD:Fe++ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Tryptophan catabolism (Homo sapiens)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Homo sapiens)
HAAO [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of carbohydrates (Homo sapiens)
Pentose phosphate pathway (Homo sapiens)
RPE dimers isomerise RU5P to XY5P (Homo sapiens)
RPE:Fe2+ dimers [cytosol] (Homo sapiens)
RPE:Fe2+ dimer [cytosol] (Homo sapiens)
RPE:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Homo sapiens)
RPEL1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)
RPE:Fe2+ dimers [cytosol] (Homo sapiens)
RPE:Fe2+ dimer [cytosol] (Homo sapiens)
RPE:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Homo sapiens)
RPEL1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Homo sapiens)
Biosynthesis of DPAn-3 SPMs (Homo sapiens)
Biosynthesis of DPAn-3-derived maresins (Homo sapiens)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Homo sapiens)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Homo sapiens)
ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Homo sapiens)
ALOX12B:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)
ALOX12/15 [cytosol] (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Homo sapiens)
ALOX15/15B [cytosol] (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Homo sapiens)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
ALOX5 is phosphorylated by MAPKAP2 (Homo sapiens)
ALOX5:Ca2+:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of porphyrins (Homo sapiens)
Heme degradation (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)
Fe2+ [cytosol]
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)
BCMO1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of RNA (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA modification in the nucleus and cytosol (Homo sapiens)
ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)
ALKBH8:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Homo sapiens)
Hypusine synthesis from eIF5A-lysine (Homo sapiens)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
DOHH:Fe++ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)
BCMO1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Homo sapiens)
PP1A(Fe and Mn cofactors) [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Homo sapiens)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Cytoprotection by HMOX1 (Mus musculus)
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
Fe2+ [cytosol]
Cellular response to hypoxia (Mus musculus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
FIH1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
![Fe2+ [cytosol] icon](/icon/R-ICO-012913.svg){kind=icon}