Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)

Stable Identifier
R-HSA-1562626
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ferritin oxidises Fe(2+) ions to Fe(3+), migrates them to its centre, and collects thousands of them as ferric hydroxide (Fe(3+)O(OH)) in the central mineral core from which they can be later remobilised (Harrison & Arrosio 1996).

Literature References
PubMed ID Title Journal Year
8695634 The ferritins: molecular properties, iron storage function and cellular regulation

Harrison, PM, Arosio, P

Biochim Biophys Acta 1996
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Catalyst Activity

ferroxidase activity of Ferritin Complex [cytosol]

Physical Entity
Ferritin Complex [cytosol] (Homo sapiens)
Activity
ferroxidase activity (GO:0004322)
Orthologous Events
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)
Authored
Stephan, R  (2011-01-10)
Reviewed
D'Eustachio, P  (2011-10-26)
Created
Jassal, B  (2011-09-05)
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