SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region

Stable Identifier
R-HSA-904830
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Ferroportin mediates iron efflux on macrophages
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SLC40A1 (MTP1 aka ferroportin or IREG1) is highly expressed on macrophages where it mediates iron efflux from the breakdown of haem (Schimanski et al. 2005). SLC40A1 colocalizes with ceruloplasmin (CP) which stablizes SLC40A1 and is necessary for the efflux reaction to occur (Texel et al. 2008). Six copper ions are required as cofactor. Ceruloplasmin (CP) also catalyses the conversion of iron from ferrous (Fe2+) to ferric form (Fe3+), thereby assisting in its transport in the plasma in association with transferrin, which can only carry iron in the ferric state. As well as being expressed on macrophages, SLC40A1 is also highly expressed in the duodenum, placenta (where it may mediate the transport of iron from maternal to foetal circulation), muscle and spleen.

Literature References
PubMed ID Title Journal Year
19021540 Ceruloplasmin in neurodegenerative diseases

Texel, SJ, Xu, X, Harris, ZL

Biochem Soc Trans 2008
15692071 In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations

Schimanski, LM, Drakesmith, H, Merryweather-Clarke, AT, Viprakasit, V, Edwards, JP, Sweetland, E, Bastin, JM, Cowley, D, Chinthammitr, Y, Robson, KJ, Townsend, AR

Blood 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
iron ion transmembrane transporter activity of SLC40A1:CP:6Cu2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created