Reactome | SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region

SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region

Stable Identifier

R-HSA-904830

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ferroportin mediates iron efflux on macrophages

ReviewStatus

5/5

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SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region

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SLC40A1 (MTP1 aka ferroportin or IREG1) is highly expressed on macrophages where it mediates iron efflux from the breakdown of haem (Schimanski et al. 2005). SLC40A1 colocalizes with ceruloplasmin (CP) which stablizes SLC40A1 and is necessary for the efflux reaction to occur (Texel et al. 2008). Six copper ions are required as cofactor. Ceruloplasmin (CP) also catalyses the conversion of iron from ferrous (Fe2+) to ferric form (Fe3+), thereby assisting in its transport in the plasma in association with transferrin, which can only carry iron in the ferric state. As well as being expressed on macrophages, SLC40A1 is also highly expressed in the duodenum, placenta (where it may mediate the transport of iron from maternal to foetal circulation), muscle and spleen.

Literature References

PubMed ID	Title	Journal	Year
15692071	In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations Viprakasit, V, Cowley, D, Bastin, JM, Schimanski, LM, Robson, KJ, Townsend, AR, Chinthammitr, Y, Merryweather-Clarke, AT, Drakesmith, H, Sweetland, E, Edwards, JP	Blood	2005
19021540	Ceruloplasmin in neurodegenerative diseases Xu, X, Texel, SJ, Harris, ZL	Biochem Soc Trans	2008