Reactome | SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol

SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol

Stable Identifier

R-HSA-435349

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes

ReviewStatus

5/5

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SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol

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The primary site for absorption of dietary iron is the duodenum. Ferrous iron (Fe2+) is taken up from the gut lumen across the apical membranes of enterocytes and released into the portal vein circulation across basolateral membranes. The human gene SLC11A2 encodes the divalent cation transporter DCT1 (NRAMP2, Natural resistance-associated macrophage protein 2). DCT1 resides on the apical membrane of enterocytes and mediates the uptake of many metal ions, particularly ferrous iron, into these cells (Tandy et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10625641	Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells Dedes, M, Williams, M, Ramesh, B, Leggett, A, Tandy, S, Lopez-Jimenez, M, Srai, SK, Sharp, P	J Biol Chem	2000