SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol

Stable Identifier
R-HSA-435349
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes
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The primary site for absorption of dietary iron is the duodenum. Ferrous iron (Fe2+) is taken up from the gut lumen across the apical membranes of enterocytes and released into the portal vein circulation across basolateral membranes. The human gene SLC11A2 encodes the divalent cation transporter DCT1 (NRAMP2, Natural resistance-associated macrophage protein 2). DCT1 resides on the apical membrane of enterocytes and mediates the uptake of many metal ions, particularly ferrous iron, into these cells (Tandy et al. 2000).

Literature References
PubMed ID Title Journal Year
10625641 Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells

Tandy, S, Williams, M, Leggett, A, Lopez-Jimenez, M, Dedes, M, Ramesh, B, Srai, SK, Sharp, P

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
iron ion transmembrane transporter activity of SLC11A2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created