EfeUOB transport Fe2+ from periplasmic space to the cytosol

Stable Identifier
R-HSA-9911598
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli O157:H7
Compartment
periplasmic space, plasma membrane, cytosol
ReviewStatus
3/5
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EfeUOB transport Fe2+ from periplasmic space to the cytosol
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Under acidic or anaerobic conditions iron may be prevalent in the reduced ferrous form (Fe2+). The virulence of pathogenic bacteria is enhanced by Fe2+ import (Stojiljkovic et al. 1993). Ferrous iron is thought to diffuse freely through the outer membrane porins. Transport through the plasma membrane is facilitated by the EfeUOB system which is dysfunctional in many non-pathogenic bacteria due to a deletion mutation. In contrast, the EfeUOB operon of the enterohaemorrhagic strain, O157:H7, lacks any frameshift and is functional (Grosse et al., 2006; Cao et al. 2007). EfeUOB belongs to the Iron/Lead Transporter (ILT) family that has homologs in bacteria and fungi.
Literature References
PubMed ID Title Journal Year
16987175 A new ferrous iron-uptake transporter, EfeU (YcdN), from Escherichia coli

Grosse, C, Scherer, J, Koch, D, Otto, M, Taudte, N, Grass, G

Mol Microbiol 2006
8472918 Escherichia coli K-12 ferrous iron uptake mutants are impaired in their ability to colonize the mouse intestine

Stojiljkovic, I, Cobeljic, M, Hantke, K

FEMS Microbiol. Lett. 1993
17627767 EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in E. coli O157:H7

Cao, J, Woodhall, MR, Alvarez, J, Cartron, ML, Andrews, SC

Mol. Microbiol. 2007
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Catalyst Activity

ferrous iron transmembrane transporter activity of EfeUOB [plasma membrane]

Physical Entity
EfeUOB [plasma membrane] (Escherichia coli O157:H7)
Activity
ferrous iron transmembrane transporter activity (GO:0015093)
Disease
Cross References
RHEA
Mondo
Authored
Stephan, R  (2019-02-19)
Created
Stephan, R  (2024-06-03)
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