MCOLN1 transports Fe2+ from endosome lumen to cytosol

Stable Identifier
R-HSA-917936
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Iron diffuses out of the endosome
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mucolipin-1 is an iron ion channel specifically expressed in endosome and lysosome membranes. It catalyzes the diffusion of Fe2+ ions into the cytosol (Dong et al, 2008).

Literature References
PubMed ID Title Journal Year
18794901 The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

Dong, XP, Cheng, X, Mills, E, Delling, M, Wang, F, Kurz, T, Xu, H

Nature 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
iron ion transmembrane transporter activity of MCOLN1 [endosome membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created