MCOLN1 transports Fe2+ from endosome lumen to cytosol

Stable Identifier
R-HSA-917936
Type
Reaction
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Iron diffuses out of the endosome
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MCOLN1 transports Fe2+ from endosome lumen to cytosol
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Mucolipin-1 is an iron ion channel specifically expressed in endosome and lysosome membranes. It catalyzes the diffusion of Fe2+ ions into the cytosol (Dong et al, 2008).

Literature References
PubMed ID Title Journal Year
18794901 The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

Xu, H, Kurz, T, Delling, M, Cheng, X, Wang, F, Mills, E, Dong, XP

Nature 2008
Participants
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Output
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as an event of
Catalyst Activity

iron ion transmembrane transporter activity of MCOLN1 [endosome membrane]

Physical Entity
MCOLN1 [endosome membrane] (Homo sapiens)
Activity
iron ion transmembrane transporter activity (GO:0005381)
Orthologous Events
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2010-07-20)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-07-30)
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