MCOLN1 transports Fe2+ from endosome lumen to cytosol

Stable Identifier
R-HSA-917936
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Iron diffuses out of the endosome
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Mucolipin-1 is an iron ion channel specifically expressed in endosome and lysosome membranes. It catalyzes the diffusion of Fe2+ ions into the cytosol (Dong et al, 2008).

Literature References
PubMed ID Title Journal Year
18794901 The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

Xu, H, Kurz, T, Delling, M, Cheng, X, Wang, F, Mills, E, Dong, XP

Nature 2008
Participants
Participates
Catalyst Activity

iron ion transmembrane transporter activity of MCOLN1 [endosome membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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