Iron is reduced and separates from mycobactin

Stable Identifier
R-HSA-1222399
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Iron is reduced and separates from mycobactin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The IrtA transporter has a flavin reductase domain very much like Fre from E.coli that can probably act as ferrisiderophore reductase to relieve incoming loaded mycobactin from its Fe3+ by reducing it to Fe2+. Furthermore Rv2895c, which co-precipitates with IrtB and therefore is probably part of the transporter complex, has such a domain as well (Farhana et al. 2008).

Literature References
PubMed ID Title Journal Year
18461140 Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron

Tyagi, AK, Ehtesham, NZ, Farhana, A, Hasnain, SE, Rathore, SS, Kumar, S, Ghosh, PC

PLoS One 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

FMN reductase (NADPH) activity of IrtAB:Rv2895c [plasma membrane]

Physical Entity
IrtAB:Rv2895c [plasma membrane] (Mycobacterium tuberculosis)
Activity
FMN reductase (NADPH) activity (GO:0052873)
Inferred From
Iron is reduced and separates from enterobactin (Escherichia coli)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
Cite Us!