The IrtA transporter has a flavin reductase domain very much like Fre from E.coli that can probably act as ferrisiderophore reductase to relieve incoming loaded mycobactin from its Fe3+ by reducing it to Fe2+. Furthermore Rv2895c, which co-precipitates with IrtB and therefore is probably part of the transporter complex, has such a domain as well (Farhana et al. 2008).
Farhana, A, Kumar, S, Rathore, SS, Ghosh, PC, Ehtesham, NZ, Tyagi, AK, Hasnain, SE
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