The IrtA transporter has a flavin reductase domain very much like Fre from E.coli that can probably act as ferrisiderophore reductase to relieve incoming loaded mycobactin from its Fe3+ by reducing it to Fe2+. Furthermore Rv2895c, which co-precipitates with IrtB and therefore is probably part of the transporter complex, has such a domain as well (Farhana et al. 2008).
Tyagi, AK, Ehtesham, NZ, Farhana, A, Hasnain, SE, Rathore, SS, Kumar, S, Ghosh, PC
FMN reductase (NADPH) activity of IrtAB:Rv2895c [plasma membrane]
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