Reactome | SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region

SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region

Stable Identifier

R-HSA-442368

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ferroportin mediates iron influx across the basolateral membrane of enterocytes

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The primary site for absorption of dietary iron is the duodenum. Ferrous iron (Fe2+) is taken up from the gut lumen across the apical membranes of enterocytes and released into the portal vein circulation across basolateral membranes.
The human gene SLC40A1 encodes the metal transporter protein MTP1 (aka ferroportin or IREG1). This protein resides on the basolateral membrane of enterocytes and mediates ferrous iron efflux into the portal vein (Schimanski et al. 2005). MTP1 colocalizes with hephaestin (HEPH) which stablizes MTP1 and is necessary for the efflux reaction to occur (Han & Kim 2007, Chen et al. 2009). As well as the dudenum, MTP1 is also highly expressed on macrophages (where it mediates iron efflux from the breakdown of haem) and the placenta (where it may mediate the transport of iron from maternal to foetal circulation). It is also expressed in muscle and spleen.

Literature References

PubMed ID	Title	Journal	Year
15692071	In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations Schimanski, LM, Drakesmith, H, Merryweather-Clarke, AT, Viprakasit, V, Edwards, JP, Sweetland, E, Bastin, JM, Cowley, D, Chinthammitr, Y, Robson, KJ, Townsend, AR	Blood	2005
17486601	Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells Han, O, Kim, EY	J Cell Biochem	2007
19452451	Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells Chen, H, Attieh, ZK, Dang, T, Huang, G, van der Hee, RM, Vulpe, C	J Cell Biochem	2009