Reactome | Fe2+ [nucleoplasm]

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Fe2+ [nucleoplasm]

Stable Identifier

R-ALL-111793

Type

Chemical Compound [SimpleEntity]

Compartment

nucleoplasm

Synonyms

iron (ferrous), Fe(II)

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Cell Cycle (Bos taurus)

- Cell Cycle, Mitotic (Bos taurus)
  - M Phase (Bos taurus)
    - Mitotic Prophase (Bos taurus)
      - Condensation of Prophase Chromosomes (Bos taurus)
        
        CDK1 phosphorylates PHF8 (Bos taurus)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Bos taurus)
        
        PHF8:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]
        
        PHF8 demethylates histone H4K20me1 (Bos taurus)
        
        PHF8:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Bos taurus)
        
        PHF8:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Bos taurus)
        
        PHF8:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Bos taurus)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Bos taurus)
        
        PHF8:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Bos taurus)
        
        PHF8:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular Senescence (Bos taurus)
    - Oxidative Stress Induced Senescence (Bos taurus)
      - KDM6B binds iron (Bos taurus)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Bos taurus)
        
        KDM6B:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]

DNA Repair (Bos taurus)

- DNA Damage Reversal (Bos taurus)
  - Reversal of alkylation damage by DNA dioxygenases (Bos taurus)
    - RNA demethylases demethylate N6-methyladenosine RNA (Bos taurus)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Bos taurus)
        
        ALKBH5:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Bos taurus)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Caenorhabditis elegans)

- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - M Phase (Caenorhabditis elegans)
    - Mitotic Prophase (Caenorhabditis elegans)
      - Condensation of Prophase Chromosomes (Caenorhabditis elegans)
        
        CDK1 phosphorylates PHF8 (Caenorhabditis elegans)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Caenorhabditis elegans)
        
        PHF8:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]
        
        PHF8 demethylates histone H4K20me1 (Caenorhabditis elegans)
        
        PHF8:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Caenorhabditis elegans)
        
        PHF8:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Caenorhabditis elegans)
        
        PHF8:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Caenorhabditis elegans)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Caenorhabditis elegans)
        
        PHF8:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Caenorhabditis elegans)
        
        PHF8:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Cellular Senescence (Caenorhabditis elegans)
    - Oxidative Stress Induced Senescence (Caenorhabditis elegans)
      - KDM6B binds iron (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Caenorhabditis elegans)
        
        KDM6B:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Canis familiaris)

- Cell Cycle, Mitotic (Canis familiaris)
  - M Phase (Canis familiaris)
    - Mitotic Prophase (Canis familiaris)
      - Condensation of Prophase Chromosomes (Canis familiaris)
        
        CDK1 phosphorylates PHF8 (Canis familiaris)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Canis familiaris)
        
        PHF8:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]
        
        PHF8 demethylates histone H4K20me1 (Canis familiaris)
        
        PHF8:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Canis familiaris)
        
        PHF8:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Canis familiaris)
        
        PHF8:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Canis familiaris)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Canis familiaris)
        
        PHF8:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Canis familiaris)
        
        PHF8:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular Senescence (Canis familiaris)
    - Oxidative Stress Induced Senescence (Canis familiaris)
      - KDM6B binds iron (Canis familiaris)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Canis familiaris)
        
        KDM6B:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]

DNA Repair (Canis familiaris)

- DNA Damage Reversal (Canis familiaris)
  - Reversal of alkylation damage by DNA dioxygenases (Canis familiaris)
    - RNA demethylases demethylate N6-methyladenosine RNA (Canis familiaris)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Canis familiaris)
        
        ALKBH5:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Canis familiaris)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Danio rerio)

- Cell Cycle, Mitotic (Danio rerio)
  - M Phase (Danio rerio)
    - Mitotic Prophase (Danio rerio)
      - Condensation of Prophase Chromosomes (Danio rerio)
        
        CDK1 phosphorylates PHF8 (Danio rerio)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        PHF8:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]
        
        PHF8 demethylates histone H4K20me1 (Danio rerio)
        
        PHF8:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Danio rerio)
        
        PHF8:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        PHF8:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Danio rerio)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Danio rerio)
        
        PHF8:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        PHF8:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Cellular Senescence (Danio rerio)
    - Oxidative Stress Induced Senescence (Danio rerio)
      - KDM6B binds iron (Danio rerio)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Danio rerio)
        
        KDM6B:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]

DNA Repair (Danio rerio)

- DNA Damage Reversal (Danio rerio)
  - Reversal of alkylation damage by DNA dioxygenases (Danio rerio)
    - RNA demethylases demethylate N6-methyladenosine RNA (Danio rerio)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Danio rerio)
        
        ALKBH5:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Danio rerio)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Dictyostelium discoideum)

- Cellular responses to stress (Dictyostelium discoideum)
  - Cellular Senescence (Dictyostelium discoideum)
    - Oxidative Stress Induced Senescence (Dictyostelium discoideum)
      - KDM6B binds iron (Dictyostelium discoideum)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Dictyostelium discoideum)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Dictyostelium discoideum)
        
        KDM6B:Fe2+ [nucleoplasm] (Dictyostelium discoideum)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular Senescence (Drosophila melanogaster)
    - Oxidative Stress Induced Senescence (Drosophila melanogaster)
      - KDM6B binds iron (Drosophila melanogaster)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Drosophila melanogaster)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Drosophila melanogaster)
        
        KDM6B:Fe2+ [nucleoplasm] (Drosophila melanogaster)
        
        Fe2+ [nucleoplasm]

DNA Repair (Gallus gallus)

- DNA Damage Reversal (Gallus gallus)
  - Reversal of alkylation damage by DNA dioxygenases (Gallus gallus)
    - RNA demethylases demethylate N6-methyladenosine RNA (Gallus gallus)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Gallus gallus)
        
        ALKBH5:Fe2+ [nucleoplasm] (Gallus gallus)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Gallus gallus)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prophase (Homo sapiens)
      - Condensation of Prophase Chromosomes (Homo sapiens)
        
        CDK1 phosphorylates PHF8 (Homo sapiens)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Homo sapiens)
        
        PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        PHF8 demethylates histone H4K20me1 (Homo sapiens)
        
        PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Homo sapiens)
        
        PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Homo sapiens)
        
        PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Homo sapiens)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Homo sapiens)
        
        PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Homo sapiens)
        
        PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - Oxidative Stress Induced Senescence (Homo sapiens)
      - Demethylation of H3K27Me3 by KDM6B stimulates p16-INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16-INK4A transcription (Homo sapiens)
        
        KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - KDM6B binds iron (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Homo sapiens)
        
        KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]

DNA Repair (Homo sapiens)

- DNA Damage Reversal (Homo sapiens)
  - Reversal of alkylation damage by DNA dioxygenases (Homo sapiens)
    - ALKBH2 mediated reversal of alkylation damage (Homo sapiens)
      - ALKBH2 binds alkylated DNA containing 1-etA (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH2:Fe2+:1-etA-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - ALKBH2 binds alkylated DNA containing 1-meA (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH2:Fe2+:1-meA-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - ALKBH2 binds alkylated dsDNA containing 3-meC (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH2:Fe2+:3-meC-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH2:Fe2+:1-etA-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH2:Fe2+:1-meA-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH2:Fe2+:3-meC-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
    - ALKBH3 mediated reversal of alkylation damage (Homo sapiens)
      - ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-meA-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:3-meC-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-etA-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-etA-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-meA-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
      - Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:3-meC-dsDNA [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] (Homo sapiens)
        
        ALKBH3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
    - RNA demethylases demethylate N6-methyladenosine RNA (Homo sapiens)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Homo sapiens)
        
        ALKBH5:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]

Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - TET1,2,3 and TDG demethylate DNA (Homo sapiens)
    - TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine (Homo sapiens)
      - TET1,2,3 [nucleoplasm] (Homo sapiens)
        
        TET1:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        TET2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        TET3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
    - TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)
      - TET1,2,3 [nucleoplasm] (Homo sapiens)
        
        TET1:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        TET2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        TET3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
    - TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (Homo sapiens)
      - TET1,2,3 [nucleoplasm] (Homo sapiens)
        
        TET1:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        TET2:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]
        
        TET3:Fe2+ [nucleoplasm] (Homo sapiens)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Prophase (Mus musculus)
      - Condensation of Prophase Chromosomes (Mus musculus)
        
        PHF8 demethylates histone H4K20me1 (Mus musculus)
        
        PHF8:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Mus musculus)
        
        PHF8:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Mus musculus)
        
        PHF8:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Mus musculus)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Mus musculus)
        
        PHF8:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Mus musculus)
        
        PHF8:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular Senescence (Mus musculus)
    - Oxidative Stress Induced Senescence (Mus musculus)
      - KDM6B binds iron (Mus musculus)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Mus musculus)
        
        KDM6B:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]

DNA Repair (Mus musculus)

- DNA Damage Reversal (Mus musculus)
  - Reversal of alkylation damage by DNA dioxygenases (Mus musculus)
    - RNA demethylases demethylate N6-methyladenosine RNA (Mus musculus)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Mus musculus)
        
        ALKBH5:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Mus musculus)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Rattus norvegicus)

- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Prophase (Rattus norvegicus)
      - Condensation of Prophase Chromosomes (Rattus norvegicus)
        
        PHF8 demethylates histone H4K20me1 (Rattus norvegicus)
        
        PHF8:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Rattus norvegicus)
        
        PHF8:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Rattus norvegicus)
        
        PHF8:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Rattus norvegicus)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Rattus norvegicus)
        
        PHF8:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Rattus norvegicus)
        
        PHF8:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular Senescence (Rattus norvegicus)
    - Oxidative Stress Induced Senescence (Rattus norvegicus)
      - KDM6B binds iron (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Rattus norvegicus)
        
        KDM6B:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]

DNA Repair (Rattus norvegicus)

- DNA Damage Reversal (Rattus norvegicus)
  - Reversal of alkylation damage by DNA dioxygenases (Rattus norvegicus)
    - RNA demethylases demethylate N6-methyladenosine RNA (Rattus norvegicus)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Rattus norvegicus)
        
        ALKBH5:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Rattus norvegicus)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - M Phase (Saccharomyces cerevisiae)
    - Mitotic Prophase (Saccharomyces cerevisiae)
      - Condensation of Prophase Chromosomes (Saccharomyces cerevisiae)
        
        PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)
        
        PHF8:Fe2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        PHF8:Fe2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        PHF8:Fe2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular Senescence (Saccharomyces cerevisiae)
    - Oxidative Stress Induced Senescence (Saccharomyces cerevisiae)
      - KDM6B binds iron (Saccharomyces cerevisiae)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Saccharomyces cerevisiae)
        
        KDM6B:Fe2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Schizosaccharomyces pombe)

- Cell Cycle, Mitotic (Schizosaccharomyces pombe)
  - M Phase (Schizosaccharomyces pombe)
    - Mitotic Prophase (Schizosaccharomyces pombe)
      - Condensation of Prophase Chromosomes (Schizosaccharomyces pombe)
        
        PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)
        
        PHF8:Fe2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        PHF8:Fe2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        PHF8:Fe2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Schizosaccharomyces pombe)

- Cellular responses to stress (Schizosaccharomyces pombe)
  - Cellular Senescence (Schizosaccharomyces pombe)
    - Oxidative Stress Induced Senescence (Schizosaccharomyces pombe)
      - KDM6B binds iron (Schizosaccharomyces pombe)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Schizosaccharomyces pombe)
        
        KDM6B:Fe2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Sus scrofa)

- Cell Cycle, Mitotic (Sus scrofa)
  - M Phase (Sus scrofa)
    - Mitotic Prophase (Sus scrofa)
      - Condensation of Prophase Chromosomes (Sus scrofa)
        
        CDK1 phosphorylates PHF8 (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        PHF8:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]
        
        PHF8 demethylates histone H4K20me1 (Sus scrofa)
        
        PHF8:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        PHF8:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        PHF8:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        PHF8:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        PHF8:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - Oxidative Stress Induced Senescence (Sus scrofa)
      - KDM6B binds iron (Sus scrofa)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Sus scrofa)
        
        KDM6B:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]

DNA Repair (Sus scrofa)

- DNA Damage Reversal (Sus scrofa)
  - Reversal of alkylation damage by DNA dioxygenases (Sus scrofa)
    - RNA demethylases demethylate N6-methyladenosine RNA (Sus scrofa)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Sus scrofa)
        
        ALKBH5:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Sus scrofa)
        
        Fe2+ [nucleoplasm]

Cell Cycle (Xenopus tropicalis)

- Cell Cycle, Mitotic (Xenopus tropicalis)
  - M Phase (Xenopus tropicalis)
    - Mitotic Prophase (Xenopus tropicalis)
      - Condensation of Prophase Chromosomes (Xenopus tropicalis)
        
        PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)
        
        PHF8:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Xenopus tropicalis)
        
        PHF8:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Xenopus tropicalis)
        
        PHF8:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]
        
        SETD8 monomethylates histone H4 (Xenopus tropicalis)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Xenopus tropicalis)
        
        PHF8:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Xenopus tropicalis)
        
        PHF8:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]

Cellular responses to external stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Cellular Senescence (Xenopus tropicalis)
    - Oxidative Stress Induced Senescence (Xenopus tropicalis)
      - KDM6B binds iron (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]
        
        KDM6B:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]
      - KDM6B demethylates H3K27me3 on p16-INK4A promoter (Xenopus tropicalis)
        
        KDM6B:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]

DNA Repair (Xenopus tropicalis)

- DNA Damage Reversal (Xenopus tropicalis)
  - Reversal of alkylation damage by DNA dioxygenases (Xenopus tropicalis)
    - RNA demethylases demethylate N6-methyladenosine RNA (Xenopus tropicalis)
      - Fe2+ [nucleoplasm]
      - RNA demethylases [nucleoplasm] (Xenopus tropicalis)
        
        ALKBH5:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]
        
        FTO:Fe2+ [nucleoplasm] (Xenopus tropicalis)
        
        Fe2+ [nucleoplasm]

External Reference Information

External Reference

iron(2+) [ChEBI:29033]

Participant Of

input

KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
KDM6B binds iron
RNA demethylases demethylate N6-methyladenosine RNA
RNA demethylases demethylate N6-methyladenosine RNA
RNA demethylases demethylate N6-methyladenosine RNA
RNA demethylases demethylate N6-methyladenosine RNA
RNA demethylases demethylate N6-methyladenosine RNA
RNA demethylases demethylate N6-methyladenosine RNA
RNA demethylases demethylate N6-methyladenosine RNA
RNA demethylases demethylate N6-methyladenosine RNA
RNA demethylases demethylate N6-methyladenosine RNA

hasComponent

ALKBH2:Fe2+ [nucleoplasm]
ALKBH2:Fe2+ [nucleoplasm]
ALKBH2:Fe2+ [nucleoplasm]
ALKBH2:Fe2+ [nucleoplasm]
ALKBH2:Fe2+ [nucleoplasm]
ALKBH2:Fe2+ [nucleoplasm]
ALKBH2:Fe2+ [nucleoplasm]
ALKBH2:Fe2+ [nucleoplasm]
ALKBH2:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH3:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
ALKBH5:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
FTO:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
KDM6B:Fe2+ [nucleoplasm]
p-2S-PHF8:Fe2+ [nucleoplasm]
p-2S-PHF8:Fe2+ [nucleoplasm]
p-2S-PHF8:Fe2+ [nucleoplasm]
p-2S-PHF8:Fe2+ [nucleoplasm]
p-2S-PHF8:Fe2+ [nucleoplasm]
p-2S-PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
PHF8:Fe2+ [nucleoplasm]
TET1:Fe2+ [nucleoplasm]
Tet1:Fe2+ [nucleoplasm]
TET2:Fe2+ [nucleoplasm]
Tet2:Fe2+ [nucleoplasm]
TET3:Fe2+ [nucleoplasm]
Tet3:Fe2+ [nucleoplasm]

Other forms of this molecule

Fe2+ [cytoplasm]

Fe2+ [mitochondrial intermembrane space]

Fe2+ [mitochondrial inner membrane]

Fe2+ [peroxisomal matrix]

Fe2+ [endoplasmic reticulum lumen]

Fe2+ [endoplasmic reticulum membrane]

Fe2+ [phagocytic vesicle lumen]

Fe2+ [mitochondrial matrix]

Fe2+ [endosome lumen]

Fe2+ [extracellular region]

Fe2+ [nuclear envelope]

Fe2+ [cytosol]

Cross References

AraCyc

FE+2

PubChem

27284

ChEBI

29033

COMPOUND

C14818, C00023

HMDB Metabolite

HMDB0000692, HMDB0015531

KEGG Gene

C14818

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