Iron is reduced and separates from enterobactin

Stable Identifier
R-ECO-1222667
Type
Reaction [transition]
Species
Escherichia coli
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Iron is reduced and separates from enterobactin
The IrtA transporter has a flavin reductase domain very much like Fre from E.coli that can probably act as ferrisiderophore reductase to relieve incoming loaded mycobactin from its Fe3+ by reducing it to Fe2+. Furthermore Rv2895c, which co-precipitates with IrtB and therefore is probably part of the transporter complex, has such a domain as well (Farhana et al. 2008).
Literature References
PubMed ID Title Journal Year
8436123 Reduction and mobilization of iron by a NAD(P)H:flavin oxidoreductase from Escherichia coli

Coves, J, Fontecave, M

Eur J Biochem 1993
Participants
Input
Output
Catalyst Activity

FMN reductase (NADPH) activity of Fre [cytosol]

Physical Entity
Fre [cytosol] (Escherichia coli)
Activity
FMN reductase (NADPH) activity (GO:0052873)
Orthologous Events
Iron is reduced and separates from mycobactin (Homo sapiens)
Authored
Stephan, R  (2011-01-10)
Created
Jassal, B  (2011-02-28)
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