BfrB stores iron

Stable Identifier
R-HSA-1562603
Type
Reaction
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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Mtb bacterioferritin BfrB oxidises Fe2+ to Fe3+, migrates them to its centre, and collects thousands of them as FeO(OH) in the central mineral core from which they can be later remobilised (Harrison & Arrosio 1996, Khare et al. 2011).

Literature References
PubMed ID Title Journal Year
8695634 The ferritins: molecular properties, iron storage function and cellular regulation

Harrison, PM, Arosio, P

Biochim Biophys Acta 1996
21494619 Ferritin structure from Mycobacterium tuberculosis: comparative study with homologues identifies extended C-terminus involved in ferroxidase activity

Gupta, V, Sauter, NK, Tyagi, AK, Nangpal, P, Khare, G, Gupta, RK

PLoS One 2011
Participants
Output
Participates
Catalyst Activity

ferroxidase activity of BfrB complex [cytosol]

Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Rhea
Authored
Reviewed
Created
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