BfrB stores iron

Stable Identifier
R-HSA-1562603
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BfrB stores iron
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mtb bacterioferritin BfrB oxidises Fe2+ to Fe3+, migrates them to its centre, and collects thousands of them as FeO(OH) in the central mineral core from which they can be later remobilised (Harrison & Arrosio 1996, Khare et al. 2011).
Literature References
PubMed ID Title Journal Year
8695634 The ferritins: molecular properties, iron storage function and cellular regulation

Harrison, PM, Arosio, P

Biochim Biophys Acta 1996
21494619 Ferritin structure from Mycobacterium tuberculosis: comparative study with homologues identifies extended C-terminus involved in ferroxidase activity

Khare, G, Gupta, V, Nangpal, P, Gupta, RK, Sauter, NK, Tyagi, AK

PLoS One 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ferroxidase activity of BfrB complex [cytosol]

Physical Entity
BfrB complex [cytosol] (Mycobacterium tuberculosis)
Activity
ferroxidase activity (GO:0004322)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Rhea
Mondo
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-09-05)
Cite Us!