BfrB stores iron

Stable Identifier
R-HSA-1562603
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
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BfrB stores iron
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Mtb bacterioferritin BfrB oxidises Fe2+ to Fe3+, migrates them to its centre, and collects thousands of them as FeO(OH) in the central mineral core from which they can be later remobilised (Harrison & Arrosio 1996, Khare et al. 2011).

Literature References
PubMed ID Title Journal Year
21494619 Ferritin structure from Mycobacterium tuberculosis: comparative study with homologues identifies extended C-terminus involved in ferroxidase activity

Khare, G, Gupta, V, Nangpal, P, Gupta, RK, Sauter, NK, Tyagi, AK

PLoS One 2011
8695634 The ferritins: molecular properties, iron storage function and cellular regulation

Harrison, PM, Arosio, P

Biochim Biophys Acta 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ferroxidase activity of BfrB complex [cytosol]
Physical Entity
BfrB complex [cytosol]
Activity
ferroxidase activity (0004322)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Target Pathogen
Rhea
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-09-05)
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