Reactome | EGR2 and SOX10-mediated initiation of Schwann cell myelination

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EGR2 and SOX10-mediated initiation of Schwann cell myelination Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
created	[InstanceEdit:9619670] Rothfels, Karen, 2018-09-18
dbId	9619665
displayName	EGR2 and SOX10-mediated initiation of Schwann cell myelination
doi	10.3180/R-HSA-9619665.1
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9675108] Nervous system development - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9613648] SOX10 dimer binds the POU3F1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9613644] SOX10-dependent POU3F1 gene expression - Homo sapiens [Reaction:R-HSA-9613768] SOX10, POU3F1 and POU3F2 bind EGR2 gene - Homo sapiens [BlackBoxEvent:R-HSA-9613760] EGR2 gene expression - Homo sapiens [Reaction:R-HSA-9614271] Autocleavage of ADGRG6 - Homo sapiens [BlackBoxEvent:R-HSA-9614273] ADGRG heterodimer translocates to plasma membrane - Homo sapiens [Reaction:R-HSA-9616116] EGR2 and SOX10 bind the MAG gene - Homo sapiens [BlackBoxEvent:R-HSA-9614778] MAG gene expression - Homo sapiens [Reaction:R-HSA-9615638] EGR2 and SOX10 bind the MBP gene - Homo sapiens [BlackBoxEvent:R-HSA-9614773] MBP gene expression - Homo sapiens [Reaction:R-HSA-9614790] EGR2, SOX10 and SMARCA4 bind the MPZ gene - Homo sapiens [BlackBoxEvent:R-HSA-9614787] MPZ gene expression - Homo sapiens [Reaction:R-HSA-9618559] EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene - Homo sapiens [BlackBoxEvent:R-HSA-9615626] PMP22 gene expression - Homo sapiens [Reaction:R-HSA-9618725] SOX10, EGR2 and NAB proteins bind the GJB1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9615477] GJB1 gene expression - Homo sapiens [Reaction:R-HSA-9619657] EGR2 and SOX10 bind the PRX gene - Homo sapiens [BlackBoxEvent:R-HSA-9619667] PRX gene expression - Homo sapiens [Reaction:R-HSA-9619669] L-PRX dimer binds DRP2 - Homo sapiens [Reaction:R-HSA-9619666] L-PRX:DRP2 binds dystroglycan and laminin-211 - Homo sapiens [BlackBoxEvent:R-HSA-9619668] L-PRX:DRP:DGC:laminin-211 interacts with UTRN - Homo sapiens [Reaction:R-HSA-9621411] EGR2 and SREBF2(1-484) dimer bind HMGCR gene - Homo sapiens [BlackBoxEvent:R-HSA-9621410] HMGCR gene expression - Homo sapiens [Reaction:R-HSA-9621400] EGR2 and SREBF2 dimer bind SCD5 gene - Homo sapiens [BlackBoxEvent:R-HSA-9621399] SCD5 gene expression - Homo sapiens [Reaction:R-HSA-9621406] EGR2 and SREBF2 dimer bind CYP51A1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9621404] CYP51A1 gene expression - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9621604] The origin and development of glial cells in peripheral nerves [LiteratureReference:9621606] The repair Schwann cell and its function in regenerating nerves [LiteratureReference:9621599] Schwann cell myelination [LiteratureReference:9615610] Myelin synthesis in the peripheral nervous system [LiteratureReference:9613705] The molecular machinery of myelin gene transcription in Schwann cells [LiteratureReference:9613718] Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	EGR2 and SOX10-mediated initiation of Schwann cell myelination
orthologousEvent	[Pathway:R-MMU-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Mus musculus [Pathway:R-RNO-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Rattus norvegicus [Pathway:R-CFA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Canis familiaris [Pathway:R-BTA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Bos taurus [Pathway:R-SSC-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Sus scrofa [Pathway:R-GGA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Gallus gallus [Pathway:R-DME-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Drosophila melanogaster [Pathway:R-CEL-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Caenorhabditis elegans [Pathway:R-DRE-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Danio rerio
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9619665
summation	[Summation:9621613] Schwann cells are glial cells of the peripheral nervous syst...
updateTrackers	[UpdateTracker:9928527] Update Tracker - [Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - v91:[removeHasEvent]

Referrals

(hasEvent)	[Pathway:R-HSA-9675108] Nervous system development
(hasEncapsulatedEvent)	[Pathway:R-HSA-9031628] NGF-stimulated transcription
(updatedInstance)	[UpdateTracker:9928527] Update Tracker - [Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - v91:[removeHasEvent]

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