Reactome | EGR2 and SOX10 bind the MBP gene

Schema > Reaction > Entries

EGR2 and SOX10 bind the MBP gene Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9615639] Rothfels, Karen, 2018-08-07
dbId	9615638
displayName	EGR2 and SOX10 bind the MBP gene
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9614773] MBP gene expression - Homo sapiens
inferredFrom	[Reaction:R-RNO-9615634] Egr2 and Sox10 bind Mbp1 gene - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-977385] EGR2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9613627] MBP gene [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-9613639] SOX10 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9615584] A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells [LiteratureReference:9615617] Functional organization of a Schwann cell enhancer [LiteratureReference:9615601] In vivo detection of Egr2 binding to target genes during peripheral nerve myelination [LiteratureReference:9615605] Interactions of Sox10 and Egr2 in myelin gene regulation [LiteratureReference:9615595] Differential Sox10 genomic occupancy in myelinating glia
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2 and SOX10 bind the MBP gene
output	[Complex:R-HSA-9615629] MBP gene:EGR2:SOX10 [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9615638
summation	[Summation:9615637] Myelin basic protein (MBP) is a key component in the myelin ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9614773] MBP gene expression
(hasEvent)	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination
(inferredTo)	[Reaction:R-RNO-9615634] Egr2 and Sox10 bind Mbp1 gene