Reactome | MAG gene expression

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MAG gene expression Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9614776] Rothfels, Karen, 2018-07-27
dbId	9614778
displayName	MAG gene expression
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Homo sapiens
inferredFrom	[Reaction:R-RNO-9616122] Egr2 and Sox10 bind the Mag gene - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-9614777] MAG gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9616082] Myelin-associated glycoprotein and its axonal receptors [LiteratureReference:9614591] Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development [LiteratureReference:9616055] MAG, myelin and overcoming growth inhibition in the CNS [LiteratureReference:9613730] Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10 [LiteratureReference:9615601] In vivo detection of Egr2 binding to target genes during peripheral nerve myelination [LiteratureReference:9615605] Interactions of Sox10 and Egr2 in myelin gene regulation [LiteratureReference:9615591] Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination [LiteratureReference:9616066] EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression [LiteratureReference:9618714] Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via G?s/G?q-mediated protein kinases A/C
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAG gene expression
output	[EntityWithAccessionedSequence:R-HSA-194456] MAG [plasma membrane]
precedingEvent	[Reaction:R-HSA-9616116] EGR2 and SOX10 bind the MAG gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9616128] Positive gene expression regulation by 'MAG gene:EGR2:SOX10 [nucleoplasm]' [PositiveGeneExpressionRegulation:9618734] Positive gene expression regulation by 'GPR98 [plasma membrane]'
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9614778
summation	[Summation:9616126] Myelin associated glycoprotein (MAG) is a low abundant compo...

Referrals

(hasEvent)	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination
(inferredTo)	[Reaction:R-RNO-9616122] Egr2 and Sox10 bind the Mag gene

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