Reactome | EGR2 gene expression

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EGR2 gene expression Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613764] Rothfels, Karen, 2018-07-18
dbId	9613760
displayName	EGR2 gene expression
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9612057] EGR2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9612009] Early growth response 1--a transcription factor in the crossfire of signal transduction cascades [LiteratureReference:9612019] Gene regulation in the immediate-early response process [LiteratureReference:9611984] Activation and function of immediate-early genes in the nervous system [LiteratureReference:9612028] Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins [LiteratureReference:9612035] The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience [LiteratureReference:9613705] The molecular machinery of myelin gene transcription in Schwann cells [LiteratureReference:9614302] Krox-20 controls myelination in the peripheral nervous system [LiteratureReference:9614264] Characterisation of cis-acting sequences reveals a biphasic, axon-dependent regulation of Krox20 during Schwann cell development [LiteratureReference:9613749] Control of myelination in Schwann cells: a Krox20 cis-regulatory element integrates Oct6, Brn2 and Sox10 activities [LiteratureReference:9614261] Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells [LiteratureReference:9613933] HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells [LiteratureReference:9614286] HDAC-mediated deacetylation of NF-?B is critical for Schwann cell myelination [LiteratureReference:9613916] Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2 gene expression
output	[EntityWithAccessionedSequence:R-HSA-977385] EGR2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9613768] SOX10, POU3F1 and POU3F2 bind EGR2 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9613762] Positive gene expression regulation by 'EGR2 gene:POU3F1:POU3F2:SOX10 [nucleoplasm]'
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9613760
summation	[Summation:9614308] EGR2 (also known as KROX20) is a member of the Early Growth ...

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(hasEvent)

[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination

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