Reactome | EGR2, SOX10 and SMARCA4 bind the MPZ gene

Schema > Reaction > Entries

EGR2, SOX10 and SMARCA4 bind the MPZ gene Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9614792] Rothfels, Karen, 2018-07-27
dbId	9614790
displayName	EGR2, SOX10 and SMARCA4 bind the MPZ gene
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9614787] MPZ gene expression - Homo sapiens
inferredFrom	[Reaction:R-RNO-9614784] Egr2, Sox10 and Smarca4 bind the Mpz gene - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-977385] EGR2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9613630] MPZ gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-201686] SMARCA4 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-9613639] SOX10 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9613746] Direct regulation of myelin protein zero expression by the Egr2 transactivator [LiteratureReference:9613730] Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10 [LiteratureReference:9613726] SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression [LiteratureReference:9614767] Protein zero gene expression is regulated by the glial transcription factor Sox10
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2, SOX10 and SMARCA4 bind the MPZ gene
output	[Complex:R-HSA-9614793] MPZ gene:EGR2:SOX10:SMARCA4 [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9614790
summation	[Summation:9614785] MPZ is a key component of the myelin sheath that surrounds a...

Referrals

(hasEvent)	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination
(precedingEvent)	[BlackBoxEvent:R-HSA-9614787] MPZ gene expression
(inferredTo)	[Reaction:R-RNO-9614784] Egr2, Sox10 and Smarca4 bind the Mpz gene

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