Reactome | SOX10 dimer binds the POU3F1 promoter

Schema > Reaction > Entries

SOX10 dimer binds the POU3F1 promoter Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613649] Rothfels, Karen, 2018-07-16
dbId	9613648
displayName	SOX10 dimer binds the POU3F1 promoter
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Homo sapiens
inferredFrom	[Reaction:R-RNO-9614293] Sox10 and Hdac2 interact to regulate expression of genes involved in peripheral myelination - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-205135] HDAC2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9613637] POU3F1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-201686] SMARCA4 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-9613639] SOX10 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9613737] Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding [LiteratureReference:9613936] Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages [LiteratureReference:9613905] A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration [LiteratureReference:9613911] A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration [LiteratureReference:9613933] HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells [LiteratureReference:9613916] Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination [LiteratureReference:9613705] The molecular machinery of myelin gene transcription in Schwann cells [LiteratureReference:9613718] Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOX10 dimer binds the POU3F1 promoter
output	[Complex:R-HSA-9613641] POU3F1 gene:SOX10 dimer:HDAC2:SMARCA4 [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9613648
summation	[Summation:9614289] SOX10 binds as a dimer to the Schwann cell enhancer (SCE) el...

Referrals

(hasEvent)	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination
(inferredTo)	[Reaction:R-RNO-9614293] Sox10 and Hdac2 interact to regulate expression of genes involved in peripheral myelination

Cite Us!