Reactome | PRX gene expression

Schema > BlackBoxEvent > Entries

PRX gene expression Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9619670] Rothfels, Karen, 2018-09-18
dbId	9619667
displayName	PRX gene expression
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Homo sapiens
followingEvent	[Reaction:R-HSA-9619669] L-PRX dimer binds DRP2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9619344] PRX gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9619308] Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy [LiteratureReference:9619283] Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping [LiteratureReference:9619292] Periaxin mutations cause recessive Dejerine-Sottas neuropathy [LiteratureReference:9619264] A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease [LiteratureReference:9619293] Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells [LiteratureReference:9619274] Differential regulation of the zinc finger genes Krox-20 and Krox-24 (Egr-1) suggests antagonistic roles in Schwann cells [LiteratureReference:9615605] Interactions of Sox10 and Egr2 in myelin gene regulation [LiteratureReference:9618536] Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve [LiteratureReference:9616066] EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PRX gene expression
output	[EntityWithAccessionedSequence:R-HSA-9619341] PRX [plasma membrane]
precedingEvent	[Reaction:R-HSA-9619657] EGR2 and SOX10 bind the PRX gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9619644] Positive gene expression regulation by 'PRX gene:EGR2:SOX10 [nucleoplasm]'
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9619667
summation	[Summation:9619653] Periaxin (PRX) is a scaffolding protein that is part of a d...

Referrals

(hasEvent)	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination
(precedingEvent)	[Reaction:R-HSA-9619669] L-PRX dimer binds DRP2