Reactome | EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene

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EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9618560] Rothfels, Karen, 2018-09-07
dbId	9618559
displayName	EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9615626] PMP22 gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-977385] EGR2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9615620] PMP22 Gene [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-9613639] SOX10 [nucleoplasm] [DefinedSet:R-HSA-9618556] TEAD1:WWTR1,YAP1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9616066] EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression [LiteratureReference:9618535] Distinct elements of the peripheral myelin protein 22 (PMP22) promoter regulate expression in Schwann cells and sensory neurons [LiteratureReference:9618539] Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves [LiteratureReference:9618558] Regulation of the PMP22 gene through an intronic enhancer [LiteratureReference:9618536] Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve [LiteratureReference:9618526] Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development [LiteratureReference:9618547] Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene
output	[Complex:R-HSA-9618555] PMP22 gene:EGR2:SOX10:TEAD1:WWTR1,YAP1 [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9618559
summation	[Summation:9618557] PMP22 gene expression is regulated during peripheral nerve m...

Referrals

(hasEvent)	[Pathway:R-HSA-9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination
(precedingEvent)	[BlackBoxEvent:R-HSA-9615626] PMP22 gene expression