Reactome | PIK3CA [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PIK3CA [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9680649] p-Y-PIK3R1:PIK3CA [cytosol] - Homo sapiens [Complex:R-HSA-2399558] PIK3R1 mutants:PIK3CA [plasma membrane] - Homo sapiens [Complex:R-HSA-9706282] active FLT3:p-Y GRB10:PI3K [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9712083] ALK mutants bind PI3KCA - Homo sapiens [Reaction:R-HSA-9703434] FLT3 fusions recruit PIK3CA through PIK3R1 - Homo sapiens [Reaction:R-HSA-9706345] Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-9698174] FLT3 mutants recruit PIK3CA through PIK3R1 - Homo sapiens [Reaction:R-HSA-1839102] BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654614] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA - Homo sapiens [Reaction:R-HSA-9698170] Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5655252] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5655245] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5655285] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-1839080] Activated cytosolic FGFR1 fusions bind PIK3CA - Homo sapiens [Reaction:R-HSA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
created	[InstanceEdit:74677] Schmidt, EE, 2003-08-20 08:52:29
dbId	74787
displayName	PIK3CA [cytosol]
endCoordinate	1068
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-9027214] Pik3ca [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-74787] Pik3ca [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-74787] PIK3CA [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-74787] PIK3CA [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-74787] PIK3CA [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-74787] pik3ca [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-74787] pik3ca [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-74787] PIK3CA [cytosol] - Gallus gallus [GenomeEncodedEntity:R-DME-74787] Ghost homologue of PIK3CA [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-74787] age-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-74787] pikA [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-74787-2] pikB [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-74787-3] pikC [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-74787-4] pikH [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-74787-5] pikG [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-74787-6] pikF [cytosol] - Dictyostelium discoideum [DefinedSet:R-DDI-74787-7] Homologues of PIK3CA [cytosol] - Dictyostelium discoideum
maxDepth	1
memberOf	[DefinedSet:R-HSA-74689] PI3K-catalytic subunit [cytosol] - Homo sapiens
modified	[InstanceEdit:1927284] Williams, MG, 2011-11-02
name	PIK3CA PI3K-p110 PI3-kinase p110 subunit alpha Phosphatidylinositol 3-kinase catalytic subunit, alpha isoform (EC 2.7.1.137) (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform PtdIns- 3-kinase p110
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-74787
startCoordinate	1
updateTrackers	[UpdateTracker:9870663] Update Tracker - [EntityWithAccessionedSequence:74787] PIK3CA [cytosol] - v38:[addName] [UpdateTracker:9871360] Update Tracker - [EntityWithAccessionedSequence:74787] PIK3CA [cytosol] - v39:[modifyEndCoordinate]

Referrals

(hasComponent)	[Complex:R-HSA-9680649] p-Y-PIK3R1:PIK3CA [cytosol] [Complex:R-HSA-9711926] PI3K-binding ALK fusions:PI3K [cytosol] [Complex:R-HSA-2399558] PIK3R1 mutants:PIK3CA [plasma membrane] [Complex:R-HSA-9703369] p-Y FLT3 fusions:GRB2:p-Y GAB2:PI3K [cytosol] [Complex:R-HSA-9706282] active FLT3:p-Y GRB10:PI3K [plasma membrane] [Complex:R-HSA-9698175] p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PI3K [plasma membrane] [Complex:R-HSA-5655267] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-5655337] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-5655217] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-1839055] p-FGFR1 mutant fusions:PI3K [cytosol] [Complex:R-HSA-1839051] pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol] [Complex:R-HSA-9860566] PIK3CA:p-Y464-PIK3R2 [cytosol] [Complex:R-HSA-1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-1806218] PIK3CA:PIK3R1 [cytosol] [Complex:R-HSA-1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] [Complex:R-HSA-198379] PI3K alpha [cytosol] [Complex:R-HSA-5654197] Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-5654195] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-5654192] Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-9698169] Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] [Complex:R-HSA-5654205] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-5654190] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-5654188] Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-5654187] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-1806270] PIK3CA:PIK3R2 [cytosol] [Complex:R-HSA-1806182] PIK3CA:PIK3R3 [cytosol] [Complex:R-HSA-5654331] Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-HSA-3080565] K63polyUb-PI3K alpha [cytosol]
(input)	[Reaction:R-HSA-9712083] ALK mutants bind PI3KCA [Reaction:R-HSA-9703434] FLT3 fusions recruit PIK3CA through PIK3R1 [Reaction:R-HSA-9706345] Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA [Reaction:R-HSA-9698170] Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA [Reaction:R-HSA-9698174] FLT3 mutants recruit PIK3CA through PIK3R1 [Reaction:R-HSA-5655252] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-HSA-5655245] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-HSA-5655285] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-HSA-1839080] Activated cytosolic FGFR1 fusions bind PIK3CA [Reaction:R-HSA-1839102] BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA [Reaction:R-HSA-5654614] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Reaction:R-HSA-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-HSA-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Reaction:R-HSA-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-HSA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Reaction:R-HSA-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Reaction:R-HSA-5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-HSA-5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
(hasMember)	[DefinedSet:R-HSA-74689] PI3K-catalytic subunit [cytosol]
(activeUnit)	[CatalystActivity:5655340] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [CatalystActivity:5655329] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [CatalystActivity:5655273] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [CatalystActivity:5655254] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [CatalystActivity:1839104] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol] [CatalystActivity:179881] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] [CatalystActivity:202288] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K bound to TRAT [plasma membrane] [CatalystActivity:186820] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane]
(updatedInstance)	[UpdateTracker:9870663] Update Tracker - [EntityWithAccessionedSequence:74787] PIK3CA [cytosol] - v38:[addName] [UpdateTracker:9871360] Update Tracker - [EntityWithAccessionedSequence:74787] PIK3CA [cytosol] - v39:[modifyEndCoordinate]

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