Reactome | Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA

Schema > Reaction > Entries

Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
dbId	5655252
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655309] gain_of_function of Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
eventOf	[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease - Homo sapiens
input	[Complex:R-HSA-5655344] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor [LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder [LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins [LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
normalReaction	[Reaction:R-HSA-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
output	[Complex:R-HSA-5655267] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655252
summation	[Summation:2085647] Activation of the PI3K pathway has been demonstrated downstr...

Referrals

(hasEvent)

[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease