Reactome | Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA

Schema > Reaction > Entries

Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654639] Rothfels, Karen, 2014-12-03
dbId	5654640
deleted	[Deleted:5655538] Deletion of instance: 1268262
diseaseReaction	[Reaction:R-HSA-5655285] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
displayName	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
eventOf	[Pathway:R-HSA-5654710] PI-3K cascade:FGFR3 - Homo sapiens
followingEvent	[Reaction:R-HSA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input	[Complex:R-HSA-5654203] Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
orthologousEvent	[Reaction:R-CEL-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Caenorhabditis elegans [Reaction:R-GGA-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Gallus gallus [Reaction:R-XTR-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Xenopus tropicalis [Reaction:R-DRE-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Danio rerio [Reaction:R-SSC-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Sus scrofa [Reaction:R-BTA-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Bos taurus [Reaction:R-CFA-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Canis familiaris [Reaction:R-RNO-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Rattus norvegicus [Reaction:R-MMU-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Mus musculus
output	[Complex:R-HSA-5654195] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654637] Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654640
summation	[Summation:188530] The Src homology 2 (SH2) domain of the phosphatidylinositol ...
updateTrackers	[UpdateTracker:9780125] Update Tracker - [Reaction:5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - v64:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780125] Update Tracker - [Reaction:5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - v64:[modifyText]
(replacementInstances)	[Deleted:5655538] Deletion of instance: 1268262
(normalReaction)	[Reaction:R-HSA-5655285] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
(hasEvent)	[Pathway:R-HSA-5654710] PI-3K cascade:FGFR3
(precedingEvent)	[Reaction:R-HSA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3