Reactome | BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA

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BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839101] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020786] Mondo:0011996
dbId	1839102
disease	[Disease:1500689] cancer [Disease:1247687] chronic myeloid leukemia
displayName	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654473] gain_of_function of p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-1839107] BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input	[Complex:R-HSA-1839048] p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol] [EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins [LiteratureReference:1982006] 8p11 myeloproliferative syndrome: a review [LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder [LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
output	[Complex:R-HSA-1839051] pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol]
precedingEvent	[Reaction:R-HSA-1839114] BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839102
summation	[Summation:2085608] Activation of the PI3K pathway has been demonstrated in the ...

Referrals

(precedingEvent)	[Reaction:R-HSA-1839107] BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3
(hasEvent)	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants

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