Reactome | Pik3ca [cytosol]

Schema > EntityWithAccessionedSequence > Entries

Pik3ca [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-3080565] K63polyUb-PI3K alpha [cytosol] - Rattus norvegicus [Complex:R-RNO-1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] - Rattus norvegicus [Complex:R-RNO-9706282] active FLT3:p-Y GRB10:PI3K [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-9706345] Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-5654614] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-9698170] Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Rattus norvegicus [Reaction:R-RNO-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10108617
displayName	Pik3ca [cytosol]
endCoordinate	1068
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-RNO-74689] PI3K-catalytic subunit [cytosol] - Rattus norvegicus
name	Pik3ca PIK3CA A0A0G2K344
referenceEntity	[ReferenceGeneProduct:uniprot:A0A0G2K344] UniProt:A0A0G2K344 Pik3ca
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74787
startCoordinate	1

Referrals

(input)	[Reaction:R-RNO-9706345] Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA [Reaction:R-RNO-9698170] Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA [Reaction:R-RNO-5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA [Reaction:R-RNO-5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-RNO-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Reaction:R-RNO-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Reaction:R-RNO-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-RNO-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Reaction:R-RNO-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-RNO-5654614] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
(hasComponent)	[Complex:R-RNO-9706282] active FLT3:p-Y GRB10:PI3K [plasma membrane] [Complex:R-RNO-3080565] K63polyUb-PI3K alpha [cytosol] [Complex:R-RNO-5654331] Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-RNO-1806182] PIK3CA:PIK3R3 [cytosol] [Complex:R-RNO-1806270] PIK3CA:PIK3R2 [cytosol] [Complex:R-RNO-5654187] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-RNO-5654188] Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-RNO-5654190] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-RNO-5654205] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-RNO-9698169] Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] [Complex:R-RNO-5654192] Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-RNO-5654195] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-RNO-5654197] Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Complex:R-RNO-198379] PI3K alpha [cytosol] [Complex:R-RNO-1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] [Complex:R-RNO-1806218] PIK3CA:PIK3R1 [cytosol] [Complex:R-RNO-1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
(activeUnit)	[CatalystActivity:10120803] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] [CatalystActivity:10125661] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K bound to TRAT [plasma membrane] [CatalystActivity:10120394] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane]
(hasMember)	[DefinedSet:R-RNO-74689] PI3K-catalytic subunit [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]

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