Reactome | FLT3 fusions recruit PIK3CA through PIK3R1

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FLT3 fusions recruit PIK3CA through PIK3R1 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9703434
disease	[Disease:1500689] cancer
displayName	FLT3 fusions recruit PIK3CA through PIK3R1
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins - Homo sapiens
input	[Complex:R-HSA-9703358] p-Y FLT fusions:GRB2:p-Y GAB2:PI3KR1 [cytosol] [EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9703191] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy [LiteratureReference:9703263] A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3? [LiteratureReference:9703182] The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3 [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9697911] p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells [LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 fusions recruit PIK3CA through PIK3R1
output	[Complex:R-HSA-9703369] p-Y FLT3 fusions:GRB2:p-Y GAB2:PI3K [cytosol]
precedingEvent	[Reaction:R-HSA-9703439] FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9703434
summation	[Summation:9703416] The 110 kDa catalytic subunit of PI3K is likely recruited to...

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[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins