Reactome | Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA

Schema > Reaction > Entries

Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654590] Rothfels, Karen, 2014-12-03
dbId	5654591
displayName	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
eventOf	[Pathway:R-HSA-5654689] PI-3K cascade:FGFR1 - Homo sapiens
followingEvent	[Reaction:R-HSA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input	[Complex:R-HSA-5654186] Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
orthologousEvent	[Reaction:R-GGA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Gallus gallus [Reaction:R-XTR-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Xenopus tropicalis [Reaction:R-SSC-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Sus scrofa [Reaction:R-BTA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Bos taurus [Reaction:R-CFA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Canis familiaris [Reaction:R-RNO-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Rattus norvegicus [Reaction:R-MMU-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Mus musculus
output	[Complex:R-HSA-5654205] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654591
summation	[Summation:188530] The Src homology 2 (SH2) domain of the phosphatidylinositol ...

Referrals

(normalReaction)	[Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA [Reaction:R-HSA-1839080] Activated cytosolic FGFR1 fusions bind PIK3CA
(hasEvent)	[Pathway:R-HSA-5654689] PI-3K cascade:FGFR1
(precedingEvent)	[Reaction:R-HSA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3