Reactome | Activated cytosolic FGFR1 fusions bind PIK3CA

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Activated cytosolic FGFR1 fusions bind PIK3CA Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839081] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1839080
disease	[Disease:1500689] cancer
displayName	Activated cytosolic FGFR1 fusions bind PIK3CA
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654441] gain_of_function of p-FGFR1 fusion mutant dimers:PIK3R1 [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input	[Complex:R-HSA-1839052] p-FGFR1 fusion mutant dimers:PIK3R1 [cytosol] [EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins [LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder [LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways [LiteratureReference:1982006] 8p11 myeloproliferative syndrome: a review
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated cytosolic FGFR1 fusions bind PIK3CA
normalReaction	[Reaction:R-HSA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
output	[Complex:R-HSA-1839055] p-FGFR1 mutant fusions:PI3K [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839080
summation	[Summation:2085608] Activation of the PI3K pathway has been demonstrated in the ...

Referrals

(hasEvent)	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants
(precedingEvent)	[Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3

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