Reactome | Recruitment of Grb2 to pFAK:NCAM1

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Recruitment of Grb2 to pFAK:NCAM1 Show undefined attributes

authored	[InstanceEdit:391809] Garapati, P V, 2009-02-24 10:31:15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:392050] Garapati, P V, 2009-02-26 17:43:29
dbId	392051
displayName	Recruitment of Grb2 to pFAK:NCAM1
edited	[InstanceEdit:391881] Garapati, P V, 2009-02-24 10:58:20
eventOf	[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth - Homo sapiens
followingEvent	[Reaction:R-HSA-392053] SOS binds Grb2 bound to pFAK:NCAM1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] [Complex:R-HSA-391848] Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:354156] Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase [LiteratureReference:391814] Cellular signalling mechanisms of neural cell adhesion molecules [LiteratureReference:375028] Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Recruitment of Grb2 to pFAK:NCAM1
orthologousEvent	[Reaction:R-CEL-392051] Recruitment of Grb2 to pFAK:NCAM1 - Caenorhabditis elegans [Reaction:R-BTA-392051] Recruitment of Grb2 to pFAK:NCAM1 - Bos taurus [Reaction:R-CFA-392051] Recruitment of Grb2 to pFAK:NCAM1 - Canis familiaris [Reaction:R-RNO-392051] Recruitment of Grb2 to pFAK:NCAM1 - Rattus norvegicus [Reaction:R-MMU-392051] Recruitment of Grb2 to pFAK:NCAM1 - Mus musculus
output	[Complex:R-HSA-392047] Grb2:pFAK bound to NCAM1:pFyn [plasma membrane]
precedingEvent	[Reaction:R-HSA-391866] Phosphorylation of FAK by Src kinase - Homo sapiens
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422107] Maness, PF, Walmod, PS, 2009-05-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392051
summation	[Summation:372629] Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK cr...
updateTrackers	[UpdateTracker:9777962] Update Tracker - [Reaction:392051] Recruitment of Grb2 to pFAK:NCAM1 - v68:[modifyText] [UpdateTracker:9790197] Update Tracker - [Reaction:392051] Recruitment of Grb2 to pFAK:NCAM1 - v34:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777962] Update Tracker - [Reaction:392051] Recruitment of Grb2 to pFAK:NCAM1 - v68:[modifyText] [UpdateTracker:9790197] Update Tracker - [Reaction:392051] Recruitment of Grb2 to pFAK:NCAM1 - v34:[modifyText]
(hasEvent)	[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth
(precedingEvent)	[Reaction:R-HSA-392053] SOS binds Grb2 bound to pFAK:NCAM1