Reactome | p-Y FLT3 fusion dimers:GRB2 [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9703356] p-Y FLT3 fusions:GRB2:p-Y GAB2 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9703430] FLT3 fusions:GRB2 bind SOS1 - Homo sapiens [Reaction:R-HSA-9703440] FLT3 fusions:GRB2 bind GAB2 - Homo sapiens
created	[InstanceEdit:9703348] Rothfels, Karen, 2020-10-06
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9703378
disease	[Disease:1500689] cancer
displayName	p-Y FLT3 fusion dimers:GRB2 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] [CandidateSet:R-HSA-9703372] p-Y FLT3 fusion dimers [cytosol]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
maxDepth	4
name	p-Y FLT3 fusion dimers:GRB2
producedByEvent	[Reaction:R-HSA-9703442] Phosphorylated FLT3 fusions bind GRB2 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9703378

(hasComponent)	[Complex:R-HSA-9703356] p-Y FLT3 fusions:GRB2:p-Y GAB2 [cytosol] [Complex:R-HSA-9703349] p-Y FLT3 fusions:GRB2:SOS1 [cytosol] [Complex:R-HSA-9703352] p-Y FLT3 fusions:GRB2:GAB2 [cytosol]
(input)	[Reaction:R-HSA-9703430] FLT3 fusions:GRB2 bind SOS1 [Reaction:R-HSA-9703440] FLT3 fusions:GRB2 bind GAB2
(output)	[Reaction:R-HSA-9703442] Phosphorylated FLT3 fusions bind GRB2

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