Reactome | Grb2 [cytosol]

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Grb2 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-9029096] GRB2-1:VAV1 [cytosol] - Mus musculus [Complex:R-MMU-9842589] GRB2:TNK2 [cytosol] - Mus musculus [Complex:R-MMU-9842595] Active LTK:p-Y IRS1:GRB2 [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-109813] GRB2-1 binds SOS1 - Mus musculus [Reaction:R-MMU-204871] Interaction of Tie2 and Grb2 - Mus musculus [Reaction:R-MMU-1295613] SPRY2 binds GRB2 - Mus musculus [Reaction:R-MMU-9842655] IRS1 recruits GRB2 to active LTK - Mus musculus [Reaction:R-MMU-354087] Recruitment of GRB2 to p-PTK2 - Mus musculus [BlackBoxEvent:R-MMU-8853793] p-5Y-RET complexes bind GRB2 - Mus musculus [Reaction:R-MMU-391153] p-4Y-SIRPA:CD47 binds GRB2-1 - Mus musculus [Reaction:R-MMU-177920] Binding of GRB2 to GAB1 - Mus musculus [Reaction:R-MMU-392051] Recruitment of Grb2 to pFAK:NCAM1 - Mus musculus [Reaction:R-MMU-388814] Grb2 binds CD28 - Mus musculus [Reaction:R-MMU-183052] CBL binds to GRB2 - Mus musculus [Reaction:R-MMU-389919] Grb2 binds pBTLA - Mus musculus [Reaction:R-MMU-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Mus musculus [Reaction:R-MMU-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Mus musculus [Reaction:R-MMU-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Mus musculus [Reaction:R-MMU-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Mus musculus [Reaction:R-MMU-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Mus musculus [Reaction:R-MMU-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Mus musculus [Reaction:R-MMU-9606887] p-CD19:VAV binds PI3K and GRB2 - Mus musculus [Reaction:R-MMU-8851919] Activated MET binds GAB1 and GRB2 - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9989218
displayName	Grb2 [cytosol]
endCoordinate	217
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8983328] GRB2 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-MMU-2197679] SH3 domain proteins [cytosol] - Mus musculus [CandidateSet:R-MMU-9019558] RHOU effectors [cytosol] - Mus musculus
name	Grb2 GRB2-1 Q60631
producedByEvent	[Reaction:R-MMU-1549564] PPTN11 dephosphorylates SPRY2 - Mus musculus
referenceEntity	[ReferenceGeneProduct:uniprot:Q60631] UniProt:Q60631 Grb2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-74686
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-MMU-9029096] GRB2-1:VAV1 [cytosol] [Complex:R-MMU-9674826] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] [Complex:R-MMU-9842589] GRB2:TNK2 [cytosol] [Complex:R-MMU-9842595] Active LTK:p-Y IRS1:GRB2 [plasma membrane] [Complex:R-MMU-8935905] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] [Complex:R-MMU-8867037] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] [Complex:R-MMU-354113] GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] [Complex:R-MMU-8854978] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] [Complex:R-MMU-8854983] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] [Complex:R-MMU-391112] p-Y428,Y452,Y469,Y495-SIRPA:CD47:GRB2-1 [plasma membrane] [Complex:R-MMU-179849] GRB2:GAB1 [cytosol] [Complex:R-MMU-180304] GRB2:Phospho-GAB1 [cytosol] [Complex:R-MMU-9604756] Active FLT3: GRB2 [plasma membrane] [Complex:R-MMU-8851942] HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] [Complex:R-MMU-109797] GRB2-1:SOS1 [cytosol] [Complex:R-MMU-204865] Grb2 bound to Tie2 [plasma membrane] [Complex:R-MMU-392044] pFAK:Grb2:Sos [cytosol] [Complex:R-MMU-983692] BLNK:GRB2:SOS1:CIN85 [cytosol] [Complex:R-MMU-392043] pFAK:Grb2 [cytosol] [Complex:R-MMU-109801] GRB2-1:p-4S-SOS1 [cytosol] [Complex:R-MMU-388786] CD28:Grb2 [plasma membrane] [Complex:R-MMU-180511] GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] [Complex:R-MMU-182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [Complex:R-MMU-182948] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] [Complex:R-MMU-182910] CBL:GRB2 [cytosol] [Complex:R-MMU-182964] p-Y371-CBL:GRB2 [cytosol] [Complex:R-MMU-1295625] PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] [Complex:R-MMU-190399] GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] [Complex:R-MMU-389921] GRB2:pBTLA:HVEM [plasma membrane] [Complex:R-MMU-8983330] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] [Complex:R-MMU-912528] GRB2:p-Y-GAB2 [cytosol] [Complex:R-MMU-912522] GRB2:GAB2 [cytosol] [Complex:R-MMU-913411] Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] [Complex:R-MMU-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-MMU-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-MMU-912799] FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] [Complex:R-MMU-1433549] GRB2:p-SHP2:p-KIT complex [plasma membrane] [Complex:R-MMU-8851921] HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] [Complex:R-MMU-8876351] p-Y-CBL:GRB2 [cytosol]
(input)	[Reaction:R-MMU-9842655] IRS1 recruits GRB2 to active LTK [Reaction:R-MMU-354087] Recruitment of GRB2 to p-PTK2 [BlackBoxEvent:R-MMU-8853793] p-5Y-RET complexes bind GRB2 [Reaction:R-MMU-391153] p-4Y-SIRPA:CD47 binds GRB2-1 [Reaction:R-MMU-177920] Binding of GRB2 to GAB1 [Reaction:R-MMU-109813] GRB2-1 binds SOS1 [Reaction:R-MMU-204871] Interaction of Tie2 and Grb2 [Reaction:R-MMU-392051] Recruitment of Grb2 to pFAK:NCAM1 [Reaction:R-MMU-9606887] p-CD19:VAV binds PI3K and GRB2 [Reaction:R-MMU-388814] Grb2 binds CD28 [Reaction:R-MMU-183052] CBL binds to GRB2 [Reaction:R-MMU-1295613] SPRY2 binds GRB2 [Reaction:R-MMU-389919] Grb2 binds pBTLA [Reaction:R-MMU-913424] The SHC1:SHIP1 complex is stabilized by GRB2 [Reaction:R-MMU-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated [Reaction:R-MMU-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 [Reaction:R-MMU-8851919] Activated MET binds GAB1 and GRB2
(output)	[Reaction:R-MMU-1549564] PPTN11 dephosphorylates SPRY2
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] [EntityWithAccessionedSequence:R-HSA-8983328] GRB2 [cytosol]
(hasMember)	[CandidateSet:R-MMU-9019558] RHOU effectors [cytosol] [DefinedSet:R-MMU-2197679] SH3 domain proteins [cytosol]

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