Reactome | Recruitment of GRB2 to p-PTK2

Schema > Reaction > Entries

Recruitment of GRB2 to p-PTK2 Show undefined attributes

authored	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:354078] Garapati, P V, 2008-06-16 17:02:05
dbId	354087
displayName	Recruitment of GRB2 to p-PTK2
edited	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
eventOf	[Pathway:R-HSA-354194] GRB2:SOS provides linkage to MAPK signaling for Integrins - Homo sapiens
followingEvent	[Reaction:R-HSA-354165] Interaction of SOS with GRB2 bound to FADK1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] [Complex:R-HSA-354080] Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:354100] The structural basis of localization and signaling by the focal adhesion targeting domain [LiteratureReference:354156] Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase [LiteratureReference:354148] Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Recruitment of GRB2 to p-PTK2
orthologousEvent	[Reaction:R-CEL-354087] Recruitment of GRB2 to p-PTK2 - Caenorhabditis elegans [Reaction:R-GGA-354087] Recruitment of GRB2 to p-PTK2 - Gallus gallus [Reaction:R-DRE-354087] Recruitment of GRB2 to p-PTK2 - Danio rerio [Reaction:R-SSC-354087] Recruitment of GRB2 to p-PTK2 - Sus scrofa [Reaction:R-BTA-354087] Recruitment of GRB2 to p-PTK2 - Bos taurus [Reaction:R-CFA-354087] Recruitment of GRB2 to p-PTK2 - Canis familiaris [Reaction:R-RNO-354087] Recruitment of GRB2 to p-PTK2 - Rattus norvegicus [Reaction:R-MMU-354087] Recruitment of GRB2 to p-PTK2 - Mus musculus
output	[Complex:R-HSA-354113] GRB2 bound to pPTK2 in Focal adhesion [plasma membrane]
precedingEvent	[Reaction:R-HSA-354124] Phosphorylation of pPTK2 by SRC - Homo sapiens
releaseDate	2008-12-17
requiredInputComponent	[EntityWithAccessionedSequence:R-HSA-354128] p-6Y-PTK2 [cytosol] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377695] Shattil, SJ, 2008-09-16 06:21:39
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-354087
summation	[Summation:372629] Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK cr...
updateTrackers	[UpdateTracker:9790277] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v34:[modifyText] [UpdateTracker:9791574] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v28:[modifyText] [UpdateTracker:9791499] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v29:[modifyText] [UpdateTracker:9778017] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v68:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790277] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v34:[modifyText] [UpdateTracker:9791574] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v28:[modifyText] [UpdateTracker:9791499] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v29:[modifyText] [UpdateTracker:9778017] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v68:[modifyText]
(hasEvent)	[Pathway:R-HSA-354194] GRB2:SOS provides linkage to MAPK signaling for Integrins
(precedingEvent)	[Reaction:R-HSA-354165] Interaction of SOS with GRB2 bound to FADK1

Cite Us!