Reactome | CBL binds to GRB2

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CBL binds to GRB2 Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47
dbId	183052
displayName	CBL binds to GRB2
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
followingEvent	[Reaction:R-HSA-183067] Localization of CBL:GRB2 to the membrane - Homo sapiens [BlackBoxEvent:R-HSA-453104] Phosphorylated SHC1 recruits GRB2:GAB2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-112199] CBL [cytosol] [EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:183083] p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CBL binds to GRB2
orthologousEvent	[Reaction:R-CEL-183052] CBL binds to GRB2 - Caenorhabditis elegans [Reaction:R-DME-183052] CBL binds to GRB2 - Drosophila melanogaster [Reaction:R-GGA-183052] CBL binds to GRB2 - Gallus gallus [Reaction:R-DRE-183052] CBL binds to GRB2 - Danio rerio [Reaction:R-SSC-183052] CBL binds to GRB2 - Sus scrofa [Reaction:R-BTA-183052] CBL binds to GRB2 - Bos taurus [Reaction:R-CFA-183052] CBL binds to GRB2 - Canis familiaris [Reaction:R-RNO-183052] CBL binds to GRB2 - Rattus norvegicus [Reaction:R-MMU-183052] CBL binds to GRB2 - Mus musculus
output	[Complex:R-HSA-182910] CBL:GRB2 [cytosol]
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-183052
summation	[Summation:188577] CBL binds multiple signalling proteins including GRB2. The C...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-453104] Phosphorylated SHC1 recruits GRB2:GAB2 [Reaction:R-HSA-183067] Localization of CBL:GRB2 to the membrane
(hasEvent)	[Pathway:R-HSA-182971] EGFR downregulation