Reactome | GRB2 [cytosol]

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GRB2 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-GGA-8935905] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] - Gallus gallus [Complex:R-GGA-8935905] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] - Gallus gallus [Complex:R-GGA-9842589] GRB2:TNK2 [cytosol] - Gallus gallus [Complex:R-GGA-9842595] Active LTK:p-Y IRS1:GRB2 [plasma membrane] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-109813] GRB2-1 binds SOS1 - Gallus gallus [Reaction:R-GGA-204871] Interaction of Tie2 and Grb2 - Gallus gallus [Reaction:R-GGA-9842655] IRS1 recruits GRB2 to active LTK - Gallus gallus [Reaction:R-GGA-177920] Binding of GRB2 to GAB1 - Gallus gallus [Reaction:R-GGA-388814] Grb2 binds CD28 - Gallus gallus [Reaction:R-GGA-183052] CBL binds to GRB2 - Gallus gallus [Reaction:R-GGA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Gallus gallus [Reaction:R-GGA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Gallus gallus [Reaction:R-GGA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Gallus gallus [Reaction:R-GGA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Gallus gallus [Reaction:R-GGA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Gallus gallus [Reaction:R-GGA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Gallus gallus [Reaction:R-GGA-391153] p-4Y-SIRPA:CD47 binds GRB2-1 - Gallus gallus [BlackBoxEvent:R-GGA-8853793] p-5Y-RET complexes bind GRB2 - Gallus gallus [Reaction:R-GGA-354087] Recruitment of GRB2 to p-PTK2 - Gallus gallus [Reaction:R-GGA-8851919] Activated MET binds GAB1 and GRB2 - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10736304
displayName	GRB2 [cytosol]
endCoordinate	217
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8983328] GRB2 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-GGA-2197679] SH3 domain proteins [cytosol] - Gallus gallus [CandidateSet:R-GGA-9019558] RHOU effectors [cytosol] - Gallus gallus
name	GRB2 GRB2-1 A0A8V1APV6
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8V1APV6] UniProt:A0A8V1APV6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49591] Gallus gallus
stId	R-GGA-74686
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-GGA-9842589] GRB2:TNK2 [cytosol] [Complex:R-GGA-9842595] Active LTK:p-Y IRS1:GRB2 [plasma membrane] [Complex:R-GGA-8935905] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] [Complex:R-GGA-179849] GRB2:GAB1 [cytosol] [Complex:R-GGA-180304] GRB2:Phospho-GAB1 [cytosol] [Complex:R-GGA-9604756] Active FLT3: GRB2 [plasma membrane] [Complex:R-GGA-8851942] HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] [Complex:R-GGA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-GGA-204865] Grb2 bound to Tie2 [plasma membrane] [Complex:R-GGA-392044] pFAK:Grb2:Sos [cytosol] [Complex:R-GGA-109801] GRB2-1:p-4S-SOS1 [cytosol] [Complex:R-GGA-388786] CD28:Grb2 [plasma membrane] [Complex:R-GGA-180511] GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] [Complex:R-GGA-182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [Complex:R-GGA-182948] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] [Complex:R-GGA-182910] CBL:GRB2 [cytosol] [Complex:R-GGA-182964] p-Y371-CBL:GRB2 [cytosol] [Complex:R-GGA-1295625] PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] [Complex:R-GGA-190399] GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] [Complex:R-GGA-8983330] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] [Complex:R-GGA-912528] GRB2:p-Y-GAB2 [cytosol] [Complex:R-GGA-912522] GRB2:GAB2 [cytosol] [Complex:R-GGA-913411] Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] [Complex:R-GGA-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-GGA-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-GGA-912799] FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] [Complex:R-GGA-1433549] GRB2:p-SHP2:p-KIT complex [plasma membrane] [Complex:R-GGA-8851921] HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] [Complex:R-GGA-8876351] p-Y-CBL:GRB2 [cytosol] [Complex:R-GGA-391112] p-Y428,Y452,Y469,Y495-SIRPA:CD47:GRB2-1 [plasma membrane] [Complex:R-GGA-8854983] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] [Complex:R-GGA-8854978] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] [Complex:R-GGA-354113] GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] [Complex:R-GGA-8867037] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane]
(input)	[Reaction:R-GGA-9842655] IRS1 recruits GRB2 to active LTK [Reaction:R-GGA-177920] Binding of GRB2 to GAB1 [Reaction:R-GGA-109813] GRB2-1 binds SOS1 [Reaction:R-GGA-204871] Interaction of Tie2 and Grb2 [Reaction:R-GGA-388814] Grb2 binds CD28 [Reaction:R-GGA-183052] CBL binds to GRB2 [Reaction:R-GGA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 [Reaction:R-GGA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated [Reaction:R-GGA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 [Reaction:R-GGA-8851919] Activated MET binds GAB1 and GRB2 [Reaction:R-GGA-391153] p-4Y-SIRPA:CD47 binds GRB2-1 [BlackBoxEvent:R-GGA-8853793] p-5Y-RET complexes bind GRB2 [Reaction:R-GGA-354087] Recruitment of GRB2 to p-PTK2
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] [EntityWithAccessionedSequence:R-HSA-8983328] GRB2 [cytosol]
(hasMember)	[CandidateSet:R-GGA-9019558] RHOU effectors [cytosol] [DefinedSet:R-GGA-2197679] SH3 domain proteins [cytosol]

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