Reactome | Interaction of Tie2 and Grb2

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Interaction of Tie2 and Grb2 Show undefined attributes

authored	[InstanceEdit:215562] Garapati, P V, de Bono, B, 2008-03-05 10:26:56
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:204777] Garapati, P V, 2007-12-03 09:53:12
dbId	204871
displayName	Interaction of Tie2 and Grb2
eventOf	[Pathway:R-HSA-210993] Tie2 Signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-210974] Interaction of SOS-1 to Tie2 bound Grb2 - Homo sapiens
input	[Complex:R-HSA-204783] ANGPT1:p-5Y,S119-TEK [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:204811] Tek/Tie2 signaling: new and old partners [LiteratureReference:204835] GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase [LiteratureReference:204862] Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	Interaction of Tie2 and Grb2
orthologousEvent	[Reaction:R-GGA-204871] Interaction of Tie2 and Grb2 - Gallus gallus [Reaction:R-XTR-204871] Interaction of Tie2 and Grb2 - Xenopus tropicalis [Reaction:R-DRE-204871] Interaction of Tie2 and Grb2 - Danio rerio [Reaction:R-SSC-204871] Interaction of Tie2 and Grb2 - Sus scrofa [Reaction:R-BTA-204871] Interaction of Tie2 and Grb2 - Bos taurus [Reaction:R-CFA-204871] Interaction of Tie2 and Grb2 - Canis familiaris [Reaction:R-RNO-204871] Interaction of Tie2 and Grb2 - Rattus norvegicus [Reaction:R-MMU-204871] Interaction of Tie2 and Grb2 - Mus musculus
output	[Complex:R-HSA-204865] Grb2 bound to Tie2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-210872] Trans-phosphorylation of Tie2 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-204871
summation	[Summation:210975] Tie2/Tek provide mitogenic signals to endothelial cells by p...

Referrals

(hasEvent)	[Pathway:R-HSA-210993] Tie2 Signaling
(precedingEvent)	[Reaction:R-HSA-210974] Interaction of SOS-1 to Tie2 bound Grb2