Reactome | TAK1-dependent IKK and NF-kappa-B activation

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TAK1-dependent IKK and NF-kappa-B activation Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:445990] Shamovsky, V, 2009-11-08
crossReference	[DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	445989
diseasePathways	[Pathway:R-HSA-5603029] IkBA variant leads to EDA-ID - Homo sapiens [Pathway:R-HSA-5603027] IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) - Homo sapiens [Pathway:R-HSA-5602636] IKBKB deficiency causes SCID - Homo sapiens
displayName	TAK1-dependent IKK and NF-kappa-B activation
doi	10.3180/R-HSA-445989.7
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Homo sapiens [Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens [Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade - Homo sapiens [Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens [Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens [Pathway:R-HSA-9020702] Interleukin-1 signaling - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5609665] CHUK, IKBKB and IKBKG form IKK complex - Homo sapiens [Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens [BlackBoxEvent:R-HSA-9758604] Ubiquitination of IKBKG by TRAF6 - Homo sapiens [Reaction:R-HSA-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Homo sapiens [Reaction:R-HSA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Homo sapiens [Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus - Homo sapiens [Pathway:R-HSA-9758274] Regulation of NF-kappa B signaling - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:208156] TAK1 is a ubiquitin-dependent kinase of MKK and IKK [LiteratureReference:437996] Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
maxDepth	3
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	TAK1-dependent IKK and NF-kappa-B activation
orthologousEvent	[Pathway:R-MMU-445989] TAK1-dependent IKK and NF-kappa-B activation - Mus musculus [Pathway:R-RNO-445989] TAK1-dependent IKK and NF-kappa-B activation - Rattus norvegicus [Pathway:R-CFA-445989] TAK1-dependent IKK and NF-kappa-B activation - Canis familiaris [Pathway:R-BTA-445989] TAK1-dependent IKK and NF-kappa-B activation - Bos taurus [Pathway:R-SSC-445989] TAK1-dependent IKK and NF-kappa-B activation - Sus scrofa [Pathway:R-DRE-445989] TAK1-dependent IKK and NF-kappa-B activation - Danio rerio [Pathway:R-XTR-445989] TAK1-dependent IKK and NF-kappa-B activation - Xenopus tropicalis [Pathway:R-GGA-445989] TAK1-dependent IKK and NF-kappa-B activation - Gallus gallus [Pathway:R-DME-445989] TAK1-dependent IKK and NF-kappa-B activation - Drosophila melanogaster [Pathway:R-DDI-445989] TAK1-dependent IKK and NF-kappa-B activation - Dictyostelium discoideum [Pathway:R-GGA-434001] TAK1 activates NFkB by phosphorylation and activation of IKKs complex - Gallus gallus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:9773242] de Martin, R, 2022-05-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-445989
summation	[Summation:500584] NF-kappa-B is sequestered in the cytoplasm in a complex with...
updateTrackers	[UpdateTracker:9790041] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v35:[modifyText, updateContainedRLE] [UpdateTracker:9788732] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v40:[updateContainedRLE] [UpdateTracker:9774683] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v81:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9778249] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v68:[addHasEvent, updateContainedRLE] [UpdateTracker:9775503] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v78:[updateContainedRLE] [UpdateTracker:9775092] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v80:[modifyText, updateContainedRLE] [UpdateTracker:9788065] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v44:[updateContainedRLE] [UpdateTracker:9788227] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v43:[updateContainedRLE] [UpdateTracker:9790291] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v34:[updateContainedRLE] [UpdateTracker:9784975] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v52:[addHasEvent] [UpdateTracker:9779671] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v65:[updateContainedRLE] [UpdateTracker:9783167] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v57:[updateContainedRLE] [UpdateTracker:9781647] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v60:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane [Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling [Pathway:R-HSA-9020702] Interleukin-1 signaling [Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade
(hasEncapsulatedEvent)	[Pathway:R-HSA-450294] MAP kinase activation [Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway [Pathway:R-HSA-9705683] SARS-CoV-2-host interactions
(normalPathway)	[Pathway:R-HSA-5603029] IkBA variant leads to EDA-ID [Pathway:R-HSA-5603027] IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) [Pathway:R-HSA-5602636] IKBKB deficiency causes SCID
(updatedInstance)	[UpdateTracker:9790041] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v35:[modifyText, updateContainedRLE] [UpdateTracker:9788732] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v40:[updateContainedRLE] [UpdateTracker:9774683] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v81:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9778249] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v68:[addHasEvent, updateContainedRLE] [UpdateTracker:9775503] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v78:[updateContainedRLE] [UpdateTracker:9775092] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v80:[modifyText, updateContainedRLE] [UpdateTracker:9788065] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v44:[updateContainedRLE] [UpdateTracker:9788227] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v43:[updateContainedRLE] [UpdateTracker:9790291] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v34:[updateContainedRLE] [UpdateTracker:9784975] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v52:[addHasEvent] [UpdateTracker:9779671] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v65:[updateContainedRLE] [UpdateTracker:9783167] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v57:[updateContainedRLE] [UpdateTracker:9781647] Update Tracker - [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation - v60:[updateContainedRLE]

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