Reactome | Active IKBKB phosphorylates NF-kappa-B inhibitor

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Active IKBKB phosphorylates NF-kappa-B inhibitor Show undefined attributes

authored	[InstanceEdit:9758273] Shamovsky, Veronica, 2021-11-09
catalystActivity	[CatalystActivity:9773806] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9773804] Shamovsky, Veronica, 2022-05-10
dbId	9773803
diseaseReaction	[FailedReaction:R-HSA-5228811] NFKBIA variant is not phosphorylated within IkBA:NF-kappaB - Homo sapiens
displayName	Active IKBKB phosphorylates NF-kappa-B inhibitor
edited	[InstanceEdit:9773904] Shamovsky, Veronica, 2022-05-10
eventOf	[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens
followingEvent	[Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-168130] NFkB inhibitor:NFkB complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:177888] Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:9630958] Double phosphorylation-induced structural changes in the signal-receiving domain of I?B? in complex with NF-?B
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Active IKBKB phosphorylates NF-kappa-B inhibitor
orthologousEvent	[Reaction:R-DME-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Drosophila melanogaster [Reaction:R-GGA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Gallus gallus [Reaction:R-SSC-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Sus scrofa [Reaction:R-BTA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Bos taurus [Reaction:R-CFA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Canis familiaris [Reaction:R-RNO-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Rattus norvegicus [Reaction:R-MMU-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol] [DefinedSet:R-HSA-177678] Phospho-NF-kappaB Inhibitor [cytosol]
precedingEvent	[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens [Reaction:R-HSA-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8952695] Negative regulation by 'NKIRAS [cytosol]'
regulationReference	[RegulationReference:9641502] Negative regulation by 'NKIRAS [cytosol]' KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:9773242] de Martin, R, 2022-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9773803
summation	[Summation:9773805] In human, IkBs (NFKBIA, NFKBIB or NFKBIE) are inhibitory pro...
systematicName	CHUK:IKBKB:IKBKG phosphorylates IkBs:NFkB

Referrals

(normalReaction)	[FailedReaction:R-HSA-5228811] NFKBIA variant is not phosphorylated within IkBA:NF-kappaB
(hasEvent)	[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation
(precedingEvent)	[Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus [NegativePrecedingEvent:9773816] Futile Cycle: Active IKBKB phosphorylates NF-kappa-B inhibitor