Reactome | Alpha-protein kinase 1 signaling pathway

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Alpha-protein kinase 1 signaling pathway Show undefined attributes

authored	[InstanceEdit:9645656] Shamovsky, Veronica, 2019-05-17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9645472] Shamovsky, Veronica, 2019-05-12
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	9645460
displayName	Alpha-protein kinase 1 signaling pathway
doi	10.3180/R-HSA-9645460.1
edited	[InstanceEdit:9657757] Shamovsky, Veronica, 2019-08-09
eventOf	[Pathway:R-HSA-168249] Innate Immune System - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:262515] cytoplasmic pattern recognition receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9645428] ALPK1 binds ADP-heptose - Homo sapiens [Reaction:R-HSA-9645524] ALPK1:ADP-heptose binds TIFA - Homo sapiens [Reaction:R-HSA-9645535] ALPK1 phosphorylates TIFA - Homo sapiens [Reaction:R-HSA-9645481] TIFA oligomerization - Homo sapiens [Reaction:R-HSA-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Homo sapiens [Reaction:R-HSA-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex - Homo sapiens [BlackBoxEvent:R-HSA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Homo sapiens [Polymerisation:R-HSA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Homo sapiens [Reaction:R-HSA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Homo sapiens [Reaction:R-HSA-9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9645451] Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose [LiteratureReference:9645517] ADP-heptose: A new innate immune modulator
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Alpha-protein kinase 1 signaling pathway ALPK1 signaling pathway
orthologousEvent	[Pathway:R-RNO-9645460] Alpha-protein kinase 1 signaling pathway - Rattus norvegicus [Pathway:R-GGA-9645460] Alpha-protein kinase 1 signaling pathway - Gallus gallus [Pathway:R-XTR-9645460] Alpha-protein kinase 1 signaling pathway - Xenopus tropicalis [Pathway:R-SSC-9645460] Alpha-protein kinase 1 signaling pathway - Sus scrofa [Pathway:R-BTA-9645460] Alpha-protein kinase 1 signaling pathway - Bos taurus [Pathway:R-CFA-9645460] Alpha-protein kinase 1 signaling pathway - Canis familiaris [Pathway:R-MMU-9645460] Alpha-protein kinase 1 signaling pathway - Mus musculus
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9647756] Gillespie, Marc E, 2019-06-03 [InstanceEdit:9652842] Shao, Feng, 2019-07-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9645460
summation	[Summation:9645484] Immune recognition of pathogen-associated molecular patterns...

Referrals

(hasEvent)

[Pathway:R-HSA-168249] Innate Immune System