Reactome | Regulation of NF-kappa B signaling

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Regulation of NF-kappa B signaling Show undefined attributes

authored	[InstanceEdit:9758466] Shamovsky, Veronica, 2021-11-12
created	[InstanceEdit:9758273] Shamovsky, Veronica, 2021-11-09
crossReference	[DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	9758274
displayName	Regulation of NF-kappa B signaling
edited	[InstanceEdit:9773904] Shamovsky, Veronica, 2022-05-10
eventOf	[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9749464] TP53 binds the IKBIP gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9749487] TP53 stimulates IKBIP gene expression - Homo sapiens [Reaction:R-HSA-9749494] IKBIP binds IKBKB and CHUK - Homo sapiens [Reaction:R-HSA-9749505] LRRC14 binds IKBKB and CHUK - Homo sapiens [Reaction:R-HSA-9749471] NLRX1 binds CHUK:IKBKB:IKBKG - Homo sapiens [Reaction:R-HSA-9750226] NLRC5 binds IKBKB and CHUK - Homo sapiens [BlackBoxEvent:R-HSA-9750946] TRAF2,6 ubiquitinates NLRC5 - Homo sapiens [BlackBoxEvent:R-HSA-9750942] USP14 deubiquitinates NLRC5 - Homo sapiens [Reaction:R-HSA-9761344] USP18 binds IKBKG within IKK complex - Homo sapiens [Reaction:R-HSA-9757954] N4BP1 binds IKBKG - Homo sapiens [BlackBoxEvent:R-HSA-9757951] CASP8 cleaves N4BP1 at D424, D490 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9761318] Inhibitory feedback control of NF-?B signalling in health and disease
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Regulation of NF-kappa B signaling
orthologousEvent	[Pathway:R-DDI-9758274] Regulation of NF-kappa B signaling - Dictyostelium discoideum [Pathway:R-DME-9758274] Regulation of NF-kappa B signaling - Drosophila melanogaster [Pathway:R-GGA-9758274] Regulation of NF-kappa B signaling - Gallus gallus [Pathway:R-XTR-9758274] Regulation of NF-kappa B signaling - Xenopus tropicalis [Pathway:R-DRE-9758274] Regulation of NF-kappa B signaling - Danio rerio [Pathway:R-SSC-9758274] Regulation of NF-kappa B signaling - Sus scrofa [Pathway:R-BTA-9758274] Regulation of NF-kappa B signaling - Bos taurus [Pathway:R-CFA-9758274] Regulation of NF-kappa B signaling - Canis familiaris [Pathway:R-RNO-9758274] Regulation of NF-kappa B signaling - Rattus norvegicus [Pathway:R-MMU-9758274] Regulation of NF-kappa B signaling - Mus musculus
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9760900] D'Eustachio, Peter, 2022-01-05 [InstanceEdit:9773242] de Martin, R, 2022-05-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9758274
summation	[Summation:9761321] Nuclear factor kappa B (NF-kappa-B, NF-?B) is activated by a...

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(hasEvent)

[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation

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