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Interleukin-1 signaling
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authored
[InstanceEdit:744679] Ray, KP, 2010-05-17
created
[InstanceEdit:9020703] Jupe, Steve, 2017-09-11
crossReference
[DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477
dbId
9020702
displayName
Interleukin-1 signaling
edited
[InstanceEdit:9028725] Jupe, Steve, 2017-11-09
eventOf
[Pathway:R-HSA-446652] Interleukin-1 family signaling - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:422899] interleukin-1-mediated signaling pathway
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-445753] IL1B,Myr82K-Myr83K-IL1A:IL1R1 - Homo sapiens
[Reaction:R-HSA-9681763] IL1R1 binds IL1R1 inhibitors - Homo sapiens
[Reaction:R-HSA-446130] Interleukin-1 receptor type 2 binds Interleukin 1 - Homo sapiens
[Reaction:R-HSA-445757] IL1 receptor antagonist protein binds Interleukin 1 receptors - Homo sapiens
[Reaction:R-HSA-445752] Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform - Homo sapiens
[Reaction:R-HSA-450133] IL1R1:IL1:IL1RAP binds MYD88 homodimer - Homo sapiens
[Reaction:R-HSA-446648] IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 - Homo sapiens
[Reaction:R-HSA-446868] The Interleukin 1 receptor complex binds Tollip - Homo sapiens
[Reaction:R-HSA-446634] IRAK4 is activated by autophosphorylation - Homo sapiens
[BlackBoxEvent:R-HSA-446684] IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation - Homo sapiens
[Reaction:R-HSA-446692] IRAK1 binds to MYD88 within the IL1R complex - Homo sapiens
[Reaction:R-HSA-446694] IRAK4 phosphorylates IRAK1 - Homo sapiens
[Reaction:R-HSA-446701] IRAK4-activated IRAK1 autophosphorylates - Homo sapiens
[Reaction:R-HSA-446862] Hyperphosphorylated IRAK1 associates with TRAF6 - Homo sapiens
[Reaction:R-HSA-507719] p62:MEKK3 binds to TRAF6 - Homo sapiens
[Reaction:R-HSA-446894] TRAF6 binding leads to IRAK1:TRAF6 release - Homo sapiens
[Reaction:R-HSA-450173] IRAK1 induces oligomerisation of TRAF6 - Homo sapiens
[Reaction:R-HSA-8948015] hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb - Homo sapiens
[Reaction:R-HSA-446877] TRAF6 is K63 poly-ubiquitinated - Homo sapiens
[BlackBoxEvent:R-HSA-8948018] UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 - Homo sapiens
[Reaction:R-HSA-446870] Polyubiquitinated TRAF6 binds the TAK1 complex - Homo sapiens
[BlackBoxEvent:R-HSA-450187] TAK1 is activated within the TAK1 complex - Homo sapiens
[Reaction:R-HSA-450690] hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 - Homo sapiens
[BlackBoxEvent:R-HSA-450827] hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. - Homo sapiens
[BlackBoxEvent:R-HSA-8948063] hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 - Homo sapiens
[Reaction:R-HSA-451418] Pellino ubiquitinates IRAK1 - Homo sapiens
[BlackBoxEvent:R-HSA-8948066] K63polyUb-IRAK1 dissociates - Homo sapiens
[Reaction:R-HSA-451561] NEMO binds polyubiquitinated IRAK1 - Homo sapiens
[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens
[Reaction:R-HSA-727819] TAK1 phosphorylates MKK6 - Homo sapiens
[Reaction:R-HSA-209087] IKBA is phosphorylated by Phospho IKKB kinase - Homo sapiens
[BlackBoxEvent:R-HSA-2730894] NFKB1:RELA translocates from the cytosol to the nucleus - Homo sapiens
[Reaction:R-HSA-209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex - Homo sapiens
[Reaction:R-HSA-209063] Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex - Homo sapiens
[BlackBoxEvent:R-HSA-209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex - Homo sapiens
[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Homo sapiens
[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:827359] Interleukin signaling
[LiteratureReference:9027452] Interleukin-1 (IL-1) pathway
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
Interleukin-1 signaling
orthologousEvent
[Pathway:R-CFA-9020702] Interleukin-1 signaling - Canis familiaris
[Pathway:R-SCE-9020702] Interleukin-1 signaling - Saccharomyces cerevisiae
[Pathway:R-SPO-9020702] Interleukin-1 signaling - Schizosaccharomyces pombe
[Pathway:R-DDI-9020702] Interleukin-1 signaling - Dictyostelium discoideum
[Pathway:R-CEL-9020702] Interleukin-1 signaling - Caenorhabditis elegans
[Pathway:R-MMU-9020702] Interleukin-1 signaling - Mus musculus
[Pathway:R-RNO-9020702] Interleukin-1 signaling - Rattus norvegicus
[Pathway:R-BTA-9020702] Interleukin-1 signaling - Bos taurus
[Pathway:R-SSC-9020702] Interleukin-1 signaling - Sus scrofa
[Pathway:R-DRE-9020702] Interleukin-1 signaling - Danio rerio
[Pathway:R-XTR-9020702] Interleukin-1 signaling - Xenopus tropicalis
[Pathway:R-GGA-9020702] Interleukin-1 signaling - Gallus gallus
[Pathway:R-DME-9020702] Interleukin-1 signaling - Drosophila melanogaster
releaseDate
2017-12-13
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:744680] Pinteaux, E, 2010-05-17
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9020702
summation
[Summation:451689] Interleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL...
Referrals
(hasEvent)
[Pathway:R-HSA-446652] Interleukin-1 family signaling
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