Reactome | TAK1-dependent IKK and NF-kappa-B activation

Schema > Pathway > Entries

TAK1-dependent IKK and NF-kappa-B activation Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050910
displayName	TAK1-dependent IKK and NF-kappa-B activation
eventOf	[Pathway:R-DDI-168164] Toll Like Receptor 3 (TLR3) Cascade - Dictyostelium discoideum [Pathway:R-DDI-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Dictyostelium discoideum [Pathway:R-DDI-9020702] Interleukin-1 signaling - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DDI-9758274] Regulation of NF-kappa B signaling - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	TAK1-dependent IKK and NF-kappa-B activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-445989
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-168164] Toll Like Receptor 3 (TLR3) Cascade [Pathway:R-DDI-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Pathway:R-DDI-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [Pathway:R-DDI-9020702] Interleukin-1 signaling [Pathway:R-DDI-937061] TRIF (TICAM1)-mediated TLR4 signaling [Pathway:R-DDI-975871] MyD88 cascade initiated on plasma membrane
(hasEncapsulatedEvent)	[Pathway:R-DDI-450294] MAP kinase activation
(inferredTo)	[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation

© 2026 Reactome

Cite Us!