Reactome | TRIF (TICAM1)-mediated TLR4 signaling

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TRIF (TICAM1)-mediated TLR4 signaling Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
created	[InstanceEdit:937065] Shamovsky, V, 2010-08-25
dbId	937061
displayName	TRIF (TICAM1)-mediated TLR4 signaling
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-166166] MyD88-independent TLR4 cascade - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1221070] TRIF-dependent toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Homo sapiens [Pathway:R-HSA-937041] IKK complex recruitment mediated by RIP1 - Homo sapiens [Pathway:R-HSA-2562578] TRIF-mediated programmed cell death - Homo sapiens [Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Homo sapiens [Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens [Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:2423825] Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways [LiteratureReference:177881] Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
maxDepth	6
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TRIF (TICAM1)-mediated TLR4 signaling
orthologousEvent	[Pathway:R-MMU-937061] TRIF (TICAM1)-mediated TLR4 signaling - Mus musculus [Pathway:R-RNO-937061] TRIF (TICAM1)-mediated TLR4 signaling - Rattus norvegicus [Pathway:R-CFA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Canis familiaris [Pathway:R-BTA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Bos taurus [Pathway:R-SSC-937061] TRIF (TICAM1)-mediated TLR4 signaling - Sus scrofa [Pathway:R-DRE-937061] TRIF (TICAM1)-mediated TLR4 signaling - Danio rerio [Pathway:R-XTR-937061] TRIF (TICAM1)-mediated TLR4 signaling - Xenopus tropicalis [Pathway:R-GGA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Gallus gallus [Pathway:R-DME-937061] TRIF (TICAM1)-mediated TLR4 signaling - Drosophila melanogaster [Pathway:R-CEL-937061] TRIF (TICAM1)-mediated TLR4 signaling - Caenorhabditis elegans [Pathway:R-DDI-937061] TRIF (TICAM1)-mediated TLR4 signaling - Dictyostelium discoideum [Pathway:R-SPO-937061] TRIF (TICAM1)-mediated TLR4 signaling - Schizosaccharomyces pombe [Pathway:R-SCE-937061] TRIF (TICAM1)-mediated TLR4 signaling - Saccharomyces cerevisiae [Pathway:R-PFA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Plasmodium falciparum
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-937061
summation	[Summation:2584547] TRIF (TICAM1) was shown to induce IRF3/7 and NF-kappa-B acti...
updateTrackers	[UpdateTracker:9782320] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v59:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778347] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v68:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9788879] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v40:[updateIndirectRLE] [UpdateTracker:9786362] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v49:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9842226] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v86:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784372] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v54:[updateContainedPathway] [UpdateTracker:9784716] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v53:[updateContainedPathway] [UpdateTracker:9789984] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v36:[updateIndirectRLE] [UpdateTracker:9780529] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v62:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783041] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v57:[updateIndirectRLE] [UpdateTracker:9774949] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v80:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9864147] Update Tracker - [Pathway:937061] TRIF (TICAM1)-mediated TLR4 signaling - v88:[updateContainedPathway] [UpdateTracker:9786295] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v50:[updateIndirectRLE] [UpdateTracker:9846726] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v84:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775738] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v78:[updateIndirectRLE] [UpdateTracker:9784972] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v52:[updateContainedPathway] [UpdateTracker:9787728] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v44:[updateIndirectRLE] [UpdateTracker:9776376] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v76:[updateIndirectRLE] [UpdateTracker:9788169] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v43:[addHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789095] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v38:[addLiteratureReference, updateContainedPathway] [UpdateTracker:9788403] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v42:[updateIndirectRLE] [UpdateTracker:9787356] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v45:[modifyText] [UpdateTracker:9779371] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v65:[updateIndirectRLE] [UpdateTracker:9788564] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v41:[updateIndirectRLE] [UpdateTracker:9781825] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v60:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9774803] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v81:[updateContainedPathway, updateIndirectRLE]

Referrals

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[Pathway:R-HSA-166166] MyD88-independent TLR4 cascade

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