Reactome | IKBKB deficiency causes SCID

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IKBKB deficiency causes SCID Show undefined attributes

authored	[InstanceEdit:5545427] Shamovsky, V, 2014-05-21
created	[InstanceEdit:5602721] Shamovsky, Veronica, 2014-06-24
crossReference	[DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12021026] Mondo:0015974 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	5602636
disease	[Disease:5433062] severe combined immunodeficiency
displayName	IKBKB deficiency causes SCID
edited	[InstanceEdit:5673719] Shamovsky, Veronica, 2015-02-09
eventOf	[Pathway:R-HSA-5602358] Diseases associated with the TLR signaling cascade - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-5228840] Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2018-12-13
literatureReference	[LiteratureReference:5228878] Deficiency of innate and acquired immunity caused by an IKBKB mutation
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	IKBKB deficiency causes SCID
normalPathway	[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621924] D'Eustachio, Peter, 2014-09-06 [InstanceEdit:5675062] McDonald, Douglas R, 2015-02-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5602636
summation	[Summation:5602674] Four patients with early-onset, life-threatening microbial i...
updateTrackers	[UpdateTracker:9778779] Update Tracker - [Pathway:5602636] IKBKB deficiency causes SCID - v67:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9778779] Update Tracker - [Pathway:5602636] IKBKB deficiency causes SCID - v67:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5602358] Diseases associated with the TLR signaling cascade

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