Reactome | NF-kappa-B inhibitor binds NF-kappa-B complex

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NF-kappa-B inhibitor binds NF-kappa-B complex Show undefined attributes

authored	[InstanceEdit:9630199] Shamovsky, Veronica, 2018-11-30
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9630925] Shamovsky, Veronica, 2018-12-03
dbId	9630923
diseaseReaction	[Reaction:R-HSA-9630921] NFKBIA variant binds NFkB complex - Homo sapiens
displayName	NF-kappa-B inhibitor binds NF-kappa-B complex
edited	[InstanceEdit:9631280] Shamovsky, Veronica, 2018-12-05
eventOf	[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens
followingEvent	[Reaction:R-HSA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Homo sapiens [Reaction:R-HSA-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Homo sapiens
input	[DefinedSet:R-HSA-168143] NFkB inhibitor [cytosol] [Complex:R-HSA-168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9630944] Structure of an IkappaBalpha/NF-kappaB complex
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	NF-kappa-B inhibitor binds NF-kappa-B complex
negativePrecedingEvent	[NegativePrecedingEvent:9773816] Futile Cycle: Active IKBKB phosphorylates NF-kappa-B inhibitor
orthologousEvent	[Reaction:R-DME-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Drosophila melanogaster [Reaction:R-GGA-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Gallus gallus [Reaction:R-SSC-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Sus scrofa [Reaction:R-BTA-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Bos taurus [Reaction:R-CFA-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Canis familiaris [Reaction:R-RNO-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Rattus norvegicus [Reaction:R-MMU-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Mus musculus
output	[Complex:R-HSA-168130] NFkB inhibitor:NFkB complex [cytosol]
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9631054] D'Eustachio, Peter, 2018-12-04 [InstanceEdit:9773242] de Martin, R, 2022-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9630923
summation	[Summation:9630927] NF-kappa-B is sequestered in the cytosol of unstimulated cel...
updateTrackers	[UpdateTracker:9775620] Update Tracker - [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - v78:[modifyText] [UpdateTracker:9774834] Update Tracker - [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - v81:[modifyText] [UpdateTracker:9775066] Update Tracker - [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - v80:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775620] Update Tracker - [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - v78:[modifyText] [UpdateTracker:9774834] Update Tracker - [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - v81:[modifyText] [UpdateTracker:9775066] Update Tracker - [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - v80:[modifyText]
(normalReaction)	[Reaction:R-HSA-9630921] NFKBIA variant binds NFkB complex
(hasEvent)	[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation
(precedingEvent)	[Reaction:R-HSA-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor [Reaction:R-HSA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor