NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression.
Thiefes, A, Wolter, S, Mushinski, JF, Hoffmann, E, Dittrich-Breiholz, O, Graue, N, Dörrie, A, Schneider, H, Wirth, D, Luckow, B, Resch, K, Kracht, M
Wang, C, Deng, L, Hong, M, Akkaraju, GR, Inoue, J, Chen, ZJ
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