Reactome | TAK1-dependent IKK and NF-kappa-B activation

TAK1-dependent IKK and NF-kappa-B activation

Stable Identifier

R-HSA-445989

DOI

10.3180/R-HSA-445989.7

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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TAK1-dependent IKK and NF-kappa-B activation

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NF-kappa-B is sequestered in the cytoplasm in a complex with inhibitor of NF-kappa-B (IkB). Almost all NF-kappa-B activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappa-B from the complex. This allows translocation of NF-kappa-B to the nucleus where it regulates gene expression.

Literature References

PubMed ID	Title	Journal	Year
15837794	Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes Kracht, M, Wolter, S, Resch, K, Dittrich-Breiholz, O, Wirth, D, Thiefes, A, Mushinski, JF, Luckow, B, Schneider, H, Graue, N, Dörrie, A, Hoffmann, E	J Biol Chem	2005
11460167	TAK1 is a ubiquitin-dependent kinase of MKK and IKK Deng, L, Inoue, J, Akkaraju, GR, Hong, M, Wang, C, Chen, ZJ	Nature	2001