NF-kappa-B is sequestered in the cytoplasm in a complex with inhibitor of NF-kappa-B (IkB). Almost all NF-kappa-B activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappa-B from the complex. This allows translocation of NF-kappa-B to the nucleus where it regulates gene expression.
Deng, L, Inoue, J, Akkaraju, GR, Hong, M, Wang, C, Chen, ZJ
Kracht, M, Wolter, S, Resch, K, Dittrich-Breiholz, O, Wirth, D, Thiefes, A, Mushinski, JF, Luckow, B, Schneider, H, Graue, N, Dörrie, A, Hoffmann, E
© 2022 Reactome
