Reactome | Nicotinate metabolism

Schema > Pathway > Entries

Nicotinate metabolism Show undefined attributes

authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
created	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
dbId	196807
deleted	[Deleted:9941554] Deletion of instance: 197264
displayName	Nicotinate metabolism
doi	10.3180/R-HSA-196807.7
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf	[Pathway:R-HSA-196849] Metabolism of water-soluble vitamins and cofactors - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:3132622] nicotinate metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-197187] ACS transforms to QUIN non-enzymatically - Homo sapiens [Reaction:R-HSA-197268] QPRT transfers PRIB to QUIN to form NAMN - Homo sapiens [Reaction:R-HSA-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens [Reaction:R-HSA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Homo sapiens [Reaction:R-HSA-8869603] SLC22A13 exchanges extracellular NCA for cytosolic urate - Homo sapiens [Reaction:R-HSA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-197186] NAPRT1 dimer transfers PRIB to NCA to form NAMN - Homo sapiens [Reaction:R-HSA-8869606] NMRK1 phosphorylates NAR to yield NAMN - Homo sapiens [Reaction:R-HSA-8869607] NMRK2 phosphorylates NAR to yield NAMN - Homo sapiens [Reaction:R-HSA-197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ - Homo sapiens [Reaction:R-HSA-8869633] NMRK1 phosphorylates NR to yield NMN - Homo sapiens [Reaction:R-HSA-8869627] NMRK2 phosphorylates NR to yield NMN - Homo sapiens [Reaction:R-HSA-8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ - Homo sapiens [Reaction:R-HSA-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens [Reaction:R-HSA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens [Reaction:R-HSA-8940070] NT5E:Zn2+ hydrolyses NAD+ - Homo sapiens [Reaction:R-HSA-8940074] NT5E:Zn2+ hydrolyses NMN - Homo sapiens [Reaction:R-HSA-8870346] BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose - Homo sapiens [Reaction:R-HSA-8938076] CD38 hydrolyses NAD+ to NAM and ADP-ribose - Homo sapiens [Reaction:R-HSA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Homo sapiens [Reaction:R-HSA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Homo sapiens [Polymerisation:R-HSA-8938073] PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) - Homo sapiens [Reaction:R-HSA-197250] NAMPT transfers PRIB to NAM to form NAMN - Homo sapiens [Reaction:R-HSA-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Homo sapiens [Reaction:R-HSA-6806966] APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX - Homo sapiens [Reaction:R-HSA-6806967] CARKD dehydrates S-NAD(P)HX to NADPH - Homo sapiens [Reaction:R-HSA-6809287] NUDT12 hydrolyses NADH to NMNH - Homo sapiens [Reaction:R-HSA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:9941551] Location, Location, Location: Compartmentalization of NAD⁺ Synthesis and Functions in Mammalian Cells [LiteratureReference:9938175] NAD⁺ metabolism and its roles in cellular processes during ageing [LiteratureReference:197218] Enzymology of NAD+ homeostasis in man
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Nicotinate metabolism
orthologousEvent	[Pathway:R-RNO-196807] Nicotinate metabolism - Rattus norvegicus [Pathway:R-MMU-196807] Nicotinate metabolism - Mus musculus [Pathway:R-CFA-196807] Nicotinate metabolism - Canis familiaris [Pathway:R-BTA-196807] Nicotinate metabolism - Bos taurus [Pathway:R-SSC-196807] Nicotinate metabolism - Sus scrofa [Pathway:R-DRE-196807] Nicotinate metabolism - Danio rerio [Pathway:R-XTR-196807] Nicotinate metabolism - Xenopus tropicalis [Pathway:R-GGA-196807] Nicotinate metabolism - Gallus gallus [Pathway:R-DME-196807] Nicotinate metabolism - Drosophila melanogaster [Pathway:R-CEL-196807] Nicotinate metabolism - Caenorhabditis elegans [Pathway:R-DDI-196807] Nicotinate metabolism - Dictyostelium discoideum [Pathway:R-SPO-196807] Nicotinate metabolism - Schizosaccharomyces pombe [Pathway:R-SCE-196807] Nicotinate metabolism - Saccharomyces cerevisiae [Pathway:R-PFA-196807] Nicotinate metabolism - Plasmodium falciparum
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9953035] Hill, David P, 2025-05-28
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-196807
summation	[Summation:197223] Nicotinate (niacin) and nicotinamide are precursors of the c...
updateTrackers	[UpdateTracker:9791103] Update Tracker - [Pathway:196807] Nicotinate metabolism - v32:[modifyText, removeHasEvent] [UpdateTracker:9781577] Update Tracker - [Pathway:196807] Nicotinate metabolism - v60:[addHasEvent, updateContainedPathway] [UpdateTracker:9782617] Update Tracker - [Pathway:196807] Nicotinate metabolism - v59:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783591] Update Tracker - [Pathway:196807] Nicotinate metabolism - v56:[updateContainedPathway] [UpdateTracker:9791593] Update Tracker - [Pathway:196807] Nicotinate metabolism - v28:[updateIndirectRLE] [UpdateTracker:9953603] Update Tracker - [Pathway:196807] Nicotinate metabolism - v93:[add_removeHasEvent, modifyText, removeLiteratureReference] [UpdateTracker:9775729] Update Tracker - [Pathway:196807] Nicotinate metabolism - v78:[updateContainedRLE] [UpdateTracker:9777052] Update Tracker - [Pathway:196807] Nicotinate metabolism - v73:[updateIndirectRLE] [UpdateTracker:9786589] Update Tracker - [Pathway:196807] Nicotinate metabolism - v49:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790687] Update Tracker - [Pathway:196807] Nicotinate metabolism - v33:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777545] Update Tracker - [Pathway:196807] Nicotinate metabolism - v70:[updateContainedRLE] [UpdateTracker:9939634] Update Tracker - [Pathway:196807] Nicotinate metabolism - v92:[removeHasEvent] [UpdateTracker:9782717] Update Tracker - [Pathway:196807] Nicotinate metabolism - v58:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-196849] Metabolism of water-soluble vitamins and cofactors
(hasEncapsulatedEvent)	[Pathway:R-HSA-71240] Tryptophan catabolism
(replacementInstances)	[Deleted:9941554] Deletion of instance: 197264
(updatedInstance)	[UpdateTracker:9791103] Update Tracker - [Pathway:196807] Nicotinate metabolism - v32:[modifyText, removeHasEvent] [UpdateTracker:9781577] Update Tracker - [Pathway:196807] Nicotinate metabolism - v60:[addHasEvent, updateContainedPathway] [UpdateTracker:9782617] Update Tracker - [Pathway:196807] Nicotinate metabolism - v59:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783591] Update Tracker - [Pathway:196807] Nicotinate metabolism - v56:[updateContainedPathway] [UpdateTracker:9791593] Update Tracker - [Pathway:196807] Nicotinate metabolism - v28:[updateIndirectRLE] [UpdateTracker:9953603] Update Tracker - [Pathway:196807] Nicotinate metabolism - v93:[add_removeHasEvent, modifyText, removeLiteratureReference] [UpdateTracker:9775729] Update Tracker - [Pathway:196807] Nicotinate metabolism - v78:[updateContainedRLE] [UpdateTracker:9777052] Update Tracker - [Pathway:196807] Nicotinate metabolism - v73:[updateIndirectRLE] [UpdateTracker:9786589] Update Tracker - [Pathway:196807] Nicotinate metabolism - v49:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790687] Update Tracker - [Pathway:196807] Nicotinate metabolism - v33:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777545] Update Tracker - [Pathway:196807] Nicotinate metabolism - v70:[updateContainedRLE] [UpdateTracker:9939634] Update Tracker - [Pathway:196807] Nicotinate metabolism - v92:[removeHasEvent] [UpdateTracker:9782717] Update Tracker - [Pathway:196807] Nicotinate metabolism - v58:[updateContainedRLE]

Cite Us!