Reactome | NNMT transfers CH3 from SAM to NAM to form MNA

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NNMT transfers CH3 from SAM to NAM to form MNA Show undefined attributes

authored	[InstanceEdit:5359433] Jassal, B, 2014-04-11
catalystActivity	[CatalystActivity:159343] nicotinamide N-methyltransferase activity of NNMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5359433] Jassal, B, 2014-04-11
crossReference	[DatabaseIdentifier:12668000] RHEA:23885 [DatabaseIdentifier:9938247] RHEA:23885
dbId	5359451
displayName	NNMT transfers CH3 from SAM to NAM to form MNA
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf	[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-197277] NAM [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5359447] Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization [LiteratureReference:5359445] Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization [LiteratureReference:5359458] Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity [LiteratureReference:5362158] 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NNMT transfers CH3 from SAM to NAM to form MNA nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine
orthologousEvent	[Reaction:R-RNO-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Rattus norvegicus [Reaction:R-CEL-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Caenorhabditis elegans [Reaction:R-XTR-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Xenopus tropicalis [Reaction:R-DRE-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Danio rerio [Reaction:R-SSC-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Sus scrofa [Reaction:R-BTA-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Bos taurus [Reaction:R-CFA-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Canis familiaris [Reaction:R-MMU-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Mus musculus
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-549282] MNA [cytosol]
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5359451
summation	[Summation:5359454] Nicotinamide N-methyltransferase (NNMT) is a cytosolic prote...
updateTrackers	[UpdateTracker:9939642] Update Tracker - [Reaction:5359451] NNMT transfers CH3 from SAM to NAM to form MNA - v92:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939642] Update Tracker - [Reaction:5359451] NNMT transfers CH3 from SAM to NAM to form MNA - v92:[modifyText]
(hasEvent)	[Pathway:R-HSA-196807] Nicotinate metabolism

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