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Schema
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Entries
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol
Show undefined attributes
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authored
[InstanceEdit:429759] Jassal, Bijay, 2009-07-21
catalystActivity
[CatalystActivity:429740] monocarboxylic acid transmembrane transporter activity of SLC5A8 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:429759] Jassal, Bijay, 2009-07-21
crossReference
[DatabaseIdentifier:12667883] RHEA:75795
[DatabaseIdentifier:12667882] RHEA:75799
[DatabaseIdentifier:12667886] RHEA:75807
[DatabaseIdentifier:12667881] RHEA:75803
[DatabaseIdentifier:12667885] RHEA:75791
[DatabaseIdentifier:9938251] RHEA:72935
[DatabaseIdentifier:12667884] RHEA:27814
[DatabaseIdentifier:9938237] RHEA:72947
[DatabaseIdentifier:9938245] RHEA:72951
[DatabaseIdentifier:9938249] RHEA:72939
[DatabaseIdentifier:9938252] RHEA:72943
[DatabaseIdentifier:9938246] RHEA:72955
dbId
429749
displayName
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol
edited
[InstanceEdit:429759] Jassal, Bijay, 2009-07-21
eventOf
[Pathway:R-HSA-428643] Organic anion transport by SLC5/17/25 transporters - Homo sapiens
[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-197186] NAPRT1 dimer transfers PRIB to NCA to form NAMN - Homo sapiens
[Reaction:R-HSA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Homo sapiens
input
[DefinedSet:R-ALL-429739] monocarboxylates transported by SLC5A8 [extracellular region]
2 ×
[SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:429768] The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter
[LiteratureReference:9938175] NAD
+
metabolism and its roles in cellular processes during ageing
[LiteratureReference:429752] Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol
(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in)
acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in)
butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in)
propanoate(out) + 2 Na(+)(out) = propanoate(in) + 2 Na(+)(in)
pyruvate(out) + 2 Na(+)(out) = pyruvate(in) + 2 Na(+)(in)
orthologousEvent
[Reaction:R-DRE-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Danio rerio
[Reaction:R-XTR-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Xenopus tropicalis
[Reaction:R-GGA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Gallus gallus
[Reaction:R-DME-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Drosophila melanogaster
[Reaction:R-CEL-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Caenorhabditis elegans
[Reaction:R-RNO-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Rattus norvegicus
[Reaction:R-BTA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Bos taurus
[Reaction:R-MMU-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Mus musculus
[Reaction:R-CFA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Canis familiaris
[Reaction:R-SSC-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Sus scrofa
output
[DefinedSet:R-ALL-429748] monocarboxylates transported by SLC5A8 [cytosol]
2 ×
[SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent
[Reaction:R-HSA-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region - Homo sapiens
[Reaction:R-HSA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2009-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:433651] He, L, 2009-08-24
[InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
revised
[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-429749
summation
[Summation:429751] The human tumour suppressor gene SLC5A8 encodes sodium-coupl...
updateTrackers
[UpdateTracker:9782464] Update Tracker - [Reaction:429749] SLC5A8 transports monocarboxylates from extracellular region to cytosol - v59:[modifyText]
[UpdateTracker:9939701] Update Tracker - [Reaction:429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - v92:[modifyText, removeLiteratureReference]
Referrals
(precedingEvent)
[NegativePrecedingEvent:9963197] Futile Cycle: SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol
[Reaction:R-HSA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT
[Reaction:R-HSA-197186] NAPRT1 dimer transfers PRIB to NCA to form NAMN
(hasEvent)
[Pathway:R-HSA-196807] Nicotinate metabolism
[Pathway:R-HSA-428643] Organic anion transport by SLC5/17/25 transporters
(updatedInstance)
[UpdateTracker:9782464] Update Tracker - [Reaction:429749] SLC5A8 transports monocarboxylates from extracellular region to cytosol - v59:[modifyText]
[UpdateTracker:9939701] Update Tracker - [Reaction:429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - v92:[modifyText, removeLiteratureReference]
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