Reactome | NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD

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NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD Show undefined attributes

authored	[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23
catalystActivity	[CatalystActivity:200494] nicotinate-nucleotide adenylyltransferase activity of 4xNMNAT3:4xMg2+ [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23
crossReference	[DatabaseIdentifier:11879972] Rhea:22861
dbId	200474
displayName	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf	[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-8938083] NAMN [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200498] Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms [LiteratureReference:200485] Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis [LiteratureReference:200473] Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]
orthologousEvent	[Reaction:R-SCE-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Saccharomyces cerevisiae [Reaction:R-SPO-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Schizosaccharomyces pombe [Reaction:R-DDI-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Dictyostelium discoideum [Reaction:R-CEL-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Caenorhabditis elegans [Reaction:R-DME-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Drosophila melanogaster [Reaction:R-GGA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Gallus gallus [Reaction:R-SSC-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Sus scrofa [Reaction:R-BTA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Bos taurus [Reaction:R-CFA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Canis familiaris [Reaction:R-RNO-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Rattus norvegicus [Reaction:R-MMU-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Mus musculus
output	[SimpleEntity:R-ALL-8938090] NAAD [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-197268] QPRT transfers PRIB to QUIN to form NAMN - Homo sapiens [Reaction:R-HSA-197250] NAMPT transfers PRIB to NAM to form NAMN - Homo sapiens [Reaction:R-HSA-8869606] NMRK1 phosphorylates NAR to yield NAMN - Homo sapiens [Reaction:R-HSA-8869607] NMRK2 phosphorylates NAR to yield NAMN - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200474
summation	[Summation:200501] NMNAT3 catalyzes the reaction of nicotinate D-ribonucleotide...

Referrals

(hasEvent)

[Pathway:R-HSA-196807] Nicotinate metabolism