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Schema
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Reaction
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Entries
NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
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authored
[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23
catalystActivity
[CatalystActivity:200494] nicotinate-nucleotide adenylyltransferase activity of 4xNMNAT3:4xMg2+ [mitochondrial matrix]
category
transition
compartment
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23
crossReference
[DatabaseIdentifier:12667998] RHEA:22861
[DatabaseIdentifier:9938183] RHEA:21361
dbId
200474
displayName
NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
edited
[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf
[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
input
[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix]
[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
[SimpleEntity:R-ALL-8938083] NAMN [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:200498] Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms
[LiteratureReference:200485] Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis
[LiteratureReference:200473] Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis
maxDepth
1
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+)
Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]
orthologousEvent
[Reaction:R-RNO-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Rattus norvegicus
[Reaction:R-SCE-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Saccharomyces cerevisiae
[Reaction:R-SPO-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Schizosaccharomyces pombe
[Reaction:R-DDI-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Dictyostelium discoideum
[Reaction:R-CEL-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Caenorhabditis elegans
[Reaction:R-DME-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Drosophila melanogaster
[Reaction:R-GGA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Gallus gallus
[Reaction:R-DRE-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Danio rerio
[Reaction:R-SSC-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Sus scrofa
[Reaction:R-BTA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Bos taurus
[Reaction:R-CFA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Canis familiaris
[Reaction:R-MMU-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Mus musculus
output
[SimpleEntity:R-ALL-8938090] NAAD [mitochondrial matrix]
[SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-197268] QPRT transfers PRIB to QUIN to form NAMN - Homo sapiens
[Reaction:R-HSA-197250] NAMPT transfers PRIB to NAM to form NAMN - Homo sapiens
[Reaction:R-HSA-8869606] NMRK1 phosphorylates NAR to yield NAMN - Homo sapiens
[Reaction:R-HSA-8869607] NMRK2 phosphorylates NAR to yield NAMN - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2006-04-24
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9953436] Hill, David P, 2025-06-02
revised
[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-200474
summation
[Summation:200501] NMNAT3 catalyzes the reaction of nicotinate D-ribonucleotide...
updateTrackers
[UpdateTracker:9775762] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v78:[add_removeOutput]
[UpdateTracker:9782813] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v58:[add_removeInput, add_removeOutput]
[UpdateTracker:9939638] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v92:[modifyText, removeInput]
[UpdateTracker:9782130] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v59:[add_removeInput, add_removeOutput]
[UpdateTracker:9777621] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v70:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9775762] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v78:[add_removeOutput]
[UpdateTracker:9782813] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v58:[add_removeInput, add_removeOutput]
[UpdateTracker:9939638] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v92:[modifyText, removeInput]
[UpdateTracker:9782130] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v59:[add_removeInput, add_removeOutput]
[UpdateTracker:9777621] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v70:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-196807] Nicotinate metabolism
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