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Schema
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Reaction
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Entries
NADSYN1 hexamer amidates NAAD to NAD+
Show undefined attributes
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authored
[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
catalystActivity
[CatalystActivity:197281] NAD+ synthase (glutamine-hydrolyzing) activity of NADSYN1 hexamer [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
crossReference
[DatabaseIdentifier:12668005] RHEA:24385
[DatabaseIdentifier:9937908] RHEA:24385
dbId
197271
displayName
NADSYN1 hexamer amidates NAAD to NAD+
edited
[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf
[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:262876] 'de novo' NAD+ biosynthetic process from L-tryptophan
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-29472] L-Gln [cytosol]
[SimpleEntity:R-ALL-197256] NAAD [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:197199] Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency.
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
NADSYN1 hexamer amidates NAAD to NAD+
deamido-NAD(+) + L-glutamine + ATP + H2O => L-glutamate + AMP + diphosphate + NAD(+) + H(+)
Amidation of deamino-NAD+ to NAD+
orthologousEvent
[Reaction:R-RNO-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Rattus norvegicus
[Reaction:R-PFA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Plasmodium falciparum
[Reaction:R-SCE-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Saccharomyces cerevisiae
[Reaction:R-SPO-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Schizosaccharomyces pombe
[Reaction:R-DDI-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Dictyostelium discoideum
[Reaction:R-CEL-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Caenorhabditis elegans
[Reaction:R-DME-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Drosophila melanogaster
[Reaction:R-GGA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Gallus gallus
[Reaction:R-XTR-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Xenopus tropicalis
[Reaction:R-DRE-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Danio rerio
[Reaction:R-SSC-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Sus scrofa
[Reaction:R-BTA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Bos taurus
[Reaction:R-CFA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Canis familiaris
[Reaction:R-MMU-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Mus musculus
output
[SimpleEntity:R-ALL-76577] AMP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29404] L-Glu [cytosol]
[SimpleEntity:R-ALL-29360] NAD+ [cytosol]
[SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent
[Reaction:R-HSA-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2005-09-26
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9953436] Hill, David P, 2025-06-02
revised
[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-197271
summation
[Summation:197246] Cytosolic hexameric NAD synthase 1 (NADSYN1) catalyses the f...
updateTrackers
[UpdateTracker:9939742] Update Tracker - [Reaction:197271] NADSYN1 hexamer amidates NAAD to NAD+ - v92:[modifyText, removeOutput]
[UpdateTracker:9782434] Update Tracker - [Reaction:197271] NADSYN1 hexamer amidates NAAD to NAD+ - v59:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9939742] Update Tracker - [Reaction:197271] NADSYN1 hexamer amidates NAAD to NAD+ - v92:[modifyText, removeOutput]
[UpdateTracker:9782434] Update Tracker - [Reaction:197271] NADSYN1 hexamer amidates NAAD to NAD+ - v59:[modifyText]
(hasEvent)
[Pathway:R-HSA-196807] Nicotinate metabolism
(precedingEvent)
[Reaction:R-HSA-197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+
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