Reactome | NADSYN1 hexamer amidates NAAD to NAD+

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NADSYN1 hexamer amidates NAAD to NAD+ Show undefined attributes

authored	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
catalystActivity	[CatalystActivity:197281] NAD+ synthase (glutamine-hydrolyzing) activity of NADSYN1 hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
crossReference	[DatabaseIdentifier:11880315] Rhea:24385
dbId	197271
displayName	NADSYN1 hexamer amidates NAAD to NAD+
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf	[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-197256] NAAD [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:197199] Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency.
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	NADSYN1 hexamer amidates NAAD to NAD+ Amidation of deamino-NAD+ to NAD+
orthologousEvent	[Reaction:R-PFA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Plasmodium falciparum [Reaction:R-SCE-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Saccharomyces cerevisiae [Reaction:R-SPO-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Schizosaccharomyces pombe [Reaction:R-DDI-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Dictyostelium discoideum [Reaction:R-CEL-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Caenorhabditis elegans [Reaction:R-DME-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Drosophila melanogaster [Reaction:R-GGA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Gallus gallus [Reaction:R-DRE-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Danio rerio [Reaction:R-SSC-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Sus scrofa [Reaction:R-BTA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Bos taurus [Reaction:R-CFA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Canis familiaris [Reaction:R-RNO-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Rattus norvegicus [Reaction:R-MMU-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-197271
summation	[Summation:197246] NAD synthases 1 and 2 (NADSYN1 and NADSYN2) catalyse the fin...

Referrals

(hasEvent)	[Pathway:R-HSA-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-HSA-197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+